dogsan PEDESENTE - Polydioxanone Synthetic Absorbable Monofilament Sterile Surgical Suture
PEDESENTE is sterile synthetic, absorbable surgical monofilament suture. The suture is made of poly(p-dioxanone) and the empirical formula is (-O-CH2- CH2-OCH2-CO-)n. Polydioxanone polymer has been shown to be non-antigenic, non-pyrogenic and elicits only a slight tissue reaction during absorption.
- PEDESENTE sutures are dyed by adding D&C Violet No.2 during polymerization to enhance visibility in tissue. The suture is also available undyed (natural, beige).
- PEDESENTE meets all requirements for synthetic absorbable surgical monofilament sutures specified at the European Pharmacopoeia (EP) and United States Pharmacopoeia (USP).
INDICATIONS
PEDESENTE sutures are indicated for use in general soft tissue approximation and/or ligation including use in pediatric cardiovascular tissue and in ophthalmic surgery. These sutures are particularly useful where the combination of an absorbable suture and extended wound support (up to six weeks) is desirable. Sutures are for single use only.
PEDESENTE is not indicated in adult cardiovascular tissue, microsurgery and neural tissue.
ACTIONS
PEDESENTE elicits a minimal initial inflammatory reaction in tissues and is eventually replaced with an in-growth of fibrous connective tissue. Progressive loss of tensile strength and eventual absorption of PEDESENTE sutures occurs by means of hydrolysis, where the polymer degrades to the monomers which are subsequently absorbed and eliminated by the body. Absorption begins as loss of tensile strength followed by a loss of mass. Studies show that approximately 75 % of the original strength is retained at two weeks after implantation. At four weeks post implantation, approximately 60 % of the original strength is retained. Absorption test in rats and in vitro hydrolysis of PEDESENTE show that absorption is minimal until about the 90th post implantation day and is essentially complete between 180 and 210 days.