Augurex - Model 14-3-3 - Protein Citrullination Analysis

Citrullination is a highly relevant post-translational modification of proteins that occurs in RA and certain other conditions. In the extracellular space, 14-3-3η becomes citrullinated (cit) in the presence of peptidylarginine deiminases (PAD) enzymes and this extracellular modified form of the protein, cit-14-3-3η, also elicits an auto-immune response that generates cit-14-3-3η specific auto-antibodies. Both the cit-14-3-3η protein and the cit-14-3-3η auto-antibodies are measurable in blood and their clinical utility is a fast-paced area of ongoing clinical research at Augurex.