GS International Trade Co.,Ltd
GS-International - Sildenafil
Property: Value/Description. Molecular Formula: C22H30N6O4S . Molecular Weight: 474.58 g/mol . Appearance: White to off-white crystalline powder. Melting Point: 187–189 °C. Boiling Point: 672.4 °C at 760 mmHg. Density: 1.4 ± 0.1 g/cm³. Solubility: - Slightly soluble in water - Soluble in DMSO, methanol; poorly soluble in ethanol. LogP (Partition Coeff.): 2.27.
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Safety and Regulatory Notes
- Contraindications: Avoid with nitrates (risk of severe hypotension) .
- Metabolism: Primarily via CYP3A4 and CYP2C9 enzymes .
- GHS Hazards: Flammable (GHS02), acute toxicity (GHS06), and health hazards
- Erectile Dysfunction (ED): Selective inhibitor of PDE5, enhancing nitric oxide (NO)-cGMP signaling to improve penile blood flow
- Pulmonary Arterial Hypertension (PAH): Vasodilator approved by EMA for improving exercise capacity in PAH patients
- Cardiovascular Diseases: Investigated for hypertension, myocardial infarction, and heart failure (preclinical/clinical studies)
- Other Uses: Potential applications in Peyronie’s disease, visual disorders, and renal injury models