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Firalis - Model Calponin-1 (CNN-1) - Smooth Muscle Counter-Part Protein
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Properties: Calponin-1 (or CNN-1) is the smooth muscle counter-part protein of the Troponin, found in the myocardium. Three isoforms have been described, the basic Calponin isoform remains highly specific to smooth muscle.
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Through binding to Actin, Calmodulin, Troponin C and Tropomyosin, it is postulated that Calponin-1 regulates the contractility of the smooth muscle.
Due to the analogy with Troponin proteins (myocardial necrosis marker) and the high tissue specificity, CNN-1 has been recently explored as a circulating marker of arterial damage.