AtlasXomics - Model DBiT-seq - Spatial Multi-Omics Platform Technology with Cellular Resolution

The DBiT-seq discovery platform combines microfluidics with next generation sequencing. The process starts by adding multi-omic probes (e.g., for mRNA, genomic DNA, or proteins) directly to a tissue section. Sequentially and orthogonally applied microfluidics chips deliver x-barcodes and y-barcodes,  creating an in situ x-y coordinate system in tissue. Each intersection area between a microfluidic row and column generates a square-shaped element of tissue which we refer to as a Tixel. The spatially tagged probes in each Tixel™ are then extracted and sequenced, and the resulting data is used to construct a multi-omic map at cellular resolution.