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  5. BrainXell - Model BX-0650 - Spinal ...

BrainXell - Model BX-0650 - Spinal Astrocytes

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Origin: Human iPSC line. Products: 2M Viable Cells/Vial - Standard (BX-0650). 1M Viable Cells/Vial - Standard (BX-0650e). Contents: 1 vial of cells and corresponding BrainXell supplement. Cryopreserved.

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  • Marker Expression and Morphology: Spinal Astrocytes (BX-0650) express key astrocyte markers GFAP (green) and S100β (red) at >90% and exhibit mature process-bearing morphologies (shown here with a DAPI stain).
  • Labelling by the spinal-specific marker HOXB4 (red) with a Hoescht stain highlights the regional specificity of the Spinal Astrocytes
  • Function: Spinal Astrocytes (BX-0650) promote mature motor neuron activity. Co-culturing motor neurons with spinal astrocytes promotes maximal calcium influx within 10 days.
  • Co-culture spinal astrocytes with motor neurons also accelerates the development of activity recorded by multi-electrode array.