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Calder Biosciences, Inc.
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Calder - Subunit Vaccines

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Targeted approach, focused responses. Substantially reduced risk vis-à-vis other modalities. Successful recombinant subunit vaccines elicit the highest. Ab responses; Shingrix vs. Zostavax, Gardasil, HBsAg (Recombivax, Engerix, Heplisav), HAV (Vaqta, Havrix).

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  • Antibodies recognize 3-D shapes/surfaces
    • Vaccines need to present surface proteins in the same 3-D shape as present on the surface of the pathogen
    • Calder’s focus: spring-loaded and metastable viral fusion proteins: best viral vaccine targets
    • Conformational stabilization needed