Model LUM-201 - Tablet for Pediatric Growth Hormone Deficiency (PGHD)

Growth hormone (GH) deficiency is the consequence of inadequate secretion of growth hormone from the pituitary gland. This results in low GH in the body, insufficient production of downstream signaling molecules required for growth, and the subsequent lack of growth. In children, this rare disorder is called pediatric growth hormone deficiency (PGHD). Secretion of GH is under strict hormonal feedback control. Growth hormone-releasing hormone (GHRH) and ghrelin are stimulators of GH production, while somatostatin activity inhibits GH production. GH is an important hormone regulating growth in childhood and adolescence.