Creative Biogene

creative biogene - AAV Production for Autophagy Flux Detection

Autophagy is a catabolic mechanism which sequesters cytoplasmic components for lysosomal-mediated degradation, including protein inclusions and damaged organelles. Autophagy has an important role in diverse physiological processes such as adaptation to nutrient starvation, cell death, embryonic development, energy metabolism, and antigen presentation, among other events. Moreover, autophagy has been highlighted as a crucial component of pathological processes such as cancer, hypoxia, pathogen infection, and neurodegeneration. Thus, the estimation of the rate of autophagy in a quantitative manner, especially in in vivo models, has become a vital need in the field. AAV Production