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BacMam Gene Delivery Services
Researchers in life science and drug discovery have used BacMam for years to transiently deliver target receptors other constructs in their cells of interest – an effective alternative to plasmid transfection or stable cell line development.
Montana Molecular provides full-service BacMam production – including DNA preperation, cloning, sequence confirmation, viral production, and qPCR to determine viral titer.
BacMam expression efficiency is greatly improved compared to plasmid transfection, enabling experiments in specialized, disease-relevant cell types. We see expression in 100% of HEK293T cells, and expression is extremely consistent from cell-to-cell, similar to stable cell lines. Researchers also use our BacMam tools in cells ranging from primary neurons to islets to macrophages and more.
In comparison to stable cell line development, a key advantage of BacMam is the flexibility to express genes across cell lines, iPSCs, and primary cultures using the same reagent. Expression levels are easily titratable, allowing rapid assay optimization. BacMam production is faster and lower cost than stable cell lines, enabling groups to screen and test species orthologues or mutations in their target proteins.