MedGenome - BCR Sequencing Service
It is estimated that there are approximately 1010–1011 B cells in a human adult. A BCR is composed of two identical heavy chains generated by recombination of V, D and J segments and two identical light chains generated by recombination of V and J segments. Human BCRs undergo recombination at these variable regions, generating a large diverse receptor profile for each cell. Utilizing targeted next-generation sequencing of these variable regions, can provide deeper insights into B-cell differentiation, BCR somatic hypermutation, class switching, and antigen specificity. Major applications of BCR repertoire profiling include diagnostic biomarker discovery, tracking known repertoire sequences and disease diagnosis.
- Support with experimental design and selection of appropriate application depending on analysis requirements, quantity and quality of input
- Higher sensitivity in detecting low frequency BCRs including samples with low input
- End-to-end solutions for extraction, sample QC, library preparation, sequencing and bioinformatics analysis
- Accurate representation of expressed BCRs vs non-functional BCRs with improved ability to call novel and low frequency clones
- Streamlined pipeline for fast & scalable analysis
- Customized reporting
- Interactive reports
- Publication-ready figures
- Improve data interpretation with support from MedGenome`s team of experts
Ordering and Data Delivery
MedGenome`s customer portal allows for easy sample submission and sample tracking during lab processing. Data QC, raw data and interactive analysis reports are delivered securely through customer portal.