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Reaction Biology Corp.
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Cell-based Epigenetic Assays Services

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Cell-based assays are valuable to probe new drug candidates in the environment of intact cells with physiologic concentrations of substrates, co-factors and pH.

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Reaction Biology offers three options for cellular epigenetic inhibitor testing:

  1. Testing of the enzymatic activity of targets via quantification of methylation or acetylation of substrates.
  2. Binding of a compound to the target protein by the NanoBRET Target Engagement Intracellular HDAC Assay and the NanoBRET Target Engagement Intracellular BET BRD Assay. Both assay formats are based on Promega`s NanoBRET technology.
  3. Testing the protein-protein interaction of bromodomains with acetylated histones in intact cells based on the NanoBRET Bromodomain/Histone Interaction Assay.