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Conventional High-Throughput-Screening (HTS) Services
High-Throughput-Screening (HTS) is the experimental method predominantly used today in the drug discovery process. In this process, typically 50.000 to 200.000 compounds, in small containers, are screened and observed for reactions between the compounds and the target.
HTS typically consists of three phases: the pilot, the primary and the secondary phase. Overall, on average, 200.000 compounds are screened. Thus, using HTS is similar to looking for a need in the haystack and the initial choice for the search area has a major impact on the success rate of the search.
Two of the major challenges in the screening process are finding the right compounds and the need to cover a wide range of the chemical space in order to understand their biological function.