InSphero AG
Diabetes Drug Testing
FromInSphero AG
Assess islet function and efficacy of diabetes drugs with a customizable study plan. The homogeneous cellular composition, organotypic function, and long-term viability of 3D InSight™ Islet Microtissues make them an ideal model for studying pancreatic islet function, regeneration, and preservation in healthy and disease states. Our services team will work with you to design and implement a custom study package tailored to your needs.
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- Choose your islet model (human or rat)
- Select your desired endpoints from the menu below
- Work with our services team to customize your study plan
SERVICES: ENDPOINTS
- β-cell function:
- Glucose-stimulated and basal insulin secretion
- Insulin content
- α-cell function:
- Glucose-regulated glucagon secretion
- Glucagon content
- Islet viability and apoptosis:
- Islet size
- ATP content
- Caspase 3/7 activity
- β-cell proliferation:
- EdU and β-cell marker costaining
- β-cell function:
- Glucose-stimulated and basal insulin secretion
- Insulin content
- Type 2 diabetes modeling:
- β-cell function and islet viability under metabolic stress
- Type 1 diabetes modeling:
- β-cell function and islet viability under immune attack or inflammation
- Pancreatic islet toxicity:
- β-cell function and islet viability under compound-induced stress