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Lucence AmpliMarkFoundational Technology for Liquid Biopsy Tests

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AmpliMark is the foundational technology behind Lucence’s liquid biopsy tests. AmpliMark uses unique molecular barcodes in this error-correction technology. It is designed to improve detection of multiple mutation types like single nucleotide variants, insertions and deletions (indels), copy number variations (CNVs), fusions and microsatellite instability (MSI).

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Data presented at ASCO20 showed >99% sensitivity of AmpliMark in detecting clinically relevant biomarkers for lung, breast, and blood cancers, at 0.1% Mutant Allele Frequency (MAF) limit of detection. AmpliMark demonstrated 97.4% concordance for the guideline-recommended EGFR mutations when comparing two orthogonal liquid biopsy platforms in lung cancer.