MtoZ Biolabs - Model gangliosides-analysis - Gangliosides Analysis Service
Gangliosides are a large class of complex lipids that are abundant in the neuronal cell membranes in the brain. These molecules consist of sphingolipids with one or more sialic acids attached to the sugar chain. As structural components of cell membranes, gangliosides have their two hydrocarbon chains embedded in the plasma membrane, while the oligosaccharides are located on the cell surface, serving as recognition points for extracellular substances or adjacent cells' surface molecules. The oligosaccharide groups act as surface markers, playing crucial roles in cell recognition, adhesion, and signal transduction.
Fonte: Wikipédia.2010.
Gangliosides provide neuroprotection by promoting neuronal development in newborns and are involved in memory and learning processes, though their mechanisms are not fully understood. Some researchers believe that gangliosides can protect cells from adverse extracellular conditions, such as low pH and degradative enzymes. They are known to facilitate interactions between cells, the extracellular matrix, and other cells. Additionally, gangliosides are implicated in cancer and Alzheimer's disease. During aging and certain neurodegenerative diseases, the distribution patterns of gangliosides change significantly. Notable alterations in ganglioside profiles have been observed in Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV1-associated dementia, and lysosomal storage diseases.
Mass spectrometry techniques are widely employed to study gangliosides. MtoZ Biolabs offers reliable, rapid, and cost-effective ganglioside analysis services, utilizing highly stable, reproducible, and sensitive systems for separation, characterization, identification, and quantification.
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com