In Vivo PK Studies

Pharmacokinetics (PK) dedicated to determining the mechanisms of a drug's absorption, biodistribution, when it eliminated from the body and what it becomes. It is a study of how an organism affects a drug. In vivo PK studies are critical to ensure drug candidates have appropriate PK properties that can be evaluated in preclinical pharmacology and safety studies. In vivo PK studies provide required and useful information that indicates human equivalent doses (HED), no effect levels (NOEL), and pharmacokinetic/pharmacodynamic (PK/PD) drivers. Conducting PK studies also allows the determination of PK parameters such as AUC, clearance, half-life, volume of distribution, Cmax, and Cmin.