Introduction of MOG

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is exclusively expressed in the CNS on the surface of myelin sheaths and oligodendrocyte processes. The function of MOG is not yet fully understood but synthetic peptide MOG35-55 is discovered to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. This autoantibody response to MOG35-55 has been observed in MS patients and MOG35-55-induced EAE C57BL/6 mice and Lewis rats.