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Mtoz Biolabs Drug Resistant Services
5 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Humans are highly organized systems comprised of approximately 3.72×1013 cells of various types, which maintain proper organ function and normal cellular homeostasis. Despite significant and revolutionary discoveries in the field of cell biology, the heterogeneity of cells still requires further investigation. Single-cell RNA sequencing (scRNA-seq) has become the latest method for revealing the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
PROTACs represent a novel strategy for protein degradation that has gained prominence recently. Utilizing bifunctional molecules, PROTACs enable the targeted ubiquitination and subsequent degradation of proteins via the UPS. PROTACs can not only offer potential therapeutic applications for a variety of conditions, including cancer, immune dysregulation, viral infections, and neurodegenerative ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteolysis targeting chimera (PROTAC) drugs offer a novel approach to disease treatment by leveraging the body's innate protein degradation pathways. In contrast to traditional small-molecule inhibitors, PROTAC drugs promote the degradation of specific proteins rather than directly inhibiting their function, thus mitigating or eliminating their role in disease progression. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteins play a pivotal role in the regulation, function, and structure of various human organs and tissues. The regulation of the synthesis and degradation of proteins is crucial for cell functionality. Protein turnover can exist in three states: equilibrium, pool expansion, and pool contraction. At equilibrium, the rate of protein synthesis matches that of degradation, leading to unchanged ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
With the increasing focus on personalized healthcare, there is a growing demand for biomarkers for early diagnosis, prognosis, patient stratification, or monitoring treatment response. Compared with genetic biomarkers, protein biomarkers provide higher degrees of differential information. Olink proteomics is based on a unique proximity extension assay (PEA) technique that enables simultaneous ...