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Mtoz Biolabs Monoclonal Antibody Services

12 services found

MtoZ Biolabs - mAb Antibody Sequencing and Recombinant Expression Services

MtoZ Biolabs - mAb Antibody Sequencing and Recombinant Expression Services

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
The inauguration of monoclonal antibodies (mAbs), derived from mice, were immunogenic in humans. These molecules were first synthesized in 1975 by Georges Köhler and César Milstein through the use of hybridoma technology. Later, in 1984, another milestone was achieved with the production of chimeric human antibodies via recombinant DNA ...
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MtoZ Biolabs - Single B-cell Screening and Antibody Research Development

MtoZ Biolabs - Single B-cell Screening and Antibody Research Development

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Monoclonal antibodies (mAbs) are monovalent proteins expressed by B cells, capable of precisely targeting 3D epitopes, which makes it a compelling therapeutic option. Over 70 monoclonal antibody drugs have received FDA approval. Monoclonal antibody drugs dramatically transform modern medicine by ...
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MtoZ Biolabs - Antibody Drug Analysis Service

MtoZ Biolabs - Antibody Drug Analysis Service

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Antibody therapies leverage human immune system antibodies to treat diseases by targeting specific proteins on pathogens or abnormal cells with exceptional precision. The development of antibody therapies has evolved from early polyclonal sera to monoclonal antibodies, and now to genetically engineered ...
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MtoZ Biolabs - Antibody-Antigen Interactions Characterization Service | HDX-MS

MtoZ Biolabs - Antibody-Antigen Interactions Characterization Service | HDX-MS

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Monoclonal antibodies (mAbs) are powerful therapeutic tools. These glycoproteins, belonging to the immunoglobulin (Ig) family, are utilized by the immune system to identify and neutralize foreign organisms or antigens. Ig’s are classified in five groups, IgA, IgD, IgE, IgG, and IgM (as α, δ, ε, γ, and μ), based on the structure of their constant regions. ...
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MtoZ Biolabs - Small Molecule Drug Screening Service-Enzymes

MtoZ Biolabs - Small Molecule Drug Screening Service-Enzymes

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Kinases, in simple terms, are enzymes that transfer the phosphate groups of ATP to substrates. Kinases catalyze the transfer of γ-phosphate groups of ATP to substrates, mediate most signal transduction, and regulate a variety of cellular activities, including proliferation, survival, apoptosis, metabolism, transcription, differentiation, and a wide range of other cellular processes. ...
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MtoZ Biolabs - Protein-Small Molecule Interactions Characterization Service

MtoZ Biolabs - Protein-Small Molecule Interactions Characterization Service

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Many drugs target proteins that function as receptors for small-molecule ligands. These ligands bind to and alter the structures of their protein targets, thus modulating their biological activities. Key protein targets in the fields of biology and pharmaceutical research include the nuclear receptors (NRs) that belong to the superfamily of ligand-dependent transcription factors, the ...
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MtoZ Biolabs - Small Molecule Drug Screening Service-Receptor Categories

MtoZ Biolabs - Small Molecule Drug Screening Service-Receptor Categories

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and binds to the ligand and another ...
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MtoZ Biolabs - Protein Active Component Identification and Quantification

MtoZ Biolabs - Protein Active Component Identification and Quantification

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, and conducive to clinical application. Protein drugs are the ...
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MtoZ Biolabs - Antibody Sequencing Service: Advanced NGS and MS Techniques

MtoZ Biolabs - Antibody Sequencing Service: Advanced NGS and MS Techniques

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Antibodies (Abs) are essential components of the adaptive immune system, which can combat infections and other harmful agents. Produced by B cells, Ab is either secreted or expressed on the plasma membrane at the present of B cell receptors (BCRs). Each Ab comprises two heavy chains (VH) and two light chains (VL). The VL each include a constant region varing only across different classes and ...
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MtoZ Biolabs - Antibody De Novo Sequencing Service for R&D | Mass Spec

MtoZ Biolabs - Antibody De Novo Sequencing Service for R&D | Mass Spec

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
Antibodies bind to various antigens with high affinity and specificity, playing a crucial role in adaptive immune response to infections and can also mediate autoimmune diseases by targeting self-antigens. Antibodies facilitate immunity by inhibiting critical stages of a pathogen's replication cycle, such as receptor binding and cellular entry, activating the complement system, or initiating ...
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MtoZ Biolabs - Antibody-Drug Conjugate (ADC) Analysis Service

MtoZ Biolabs - Antibody-Drug Conjugate (ADC) Analysis Service

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers highly sensitive and accurate Antibody-Drug Conjugate (ADC) Analysis service based on high-throughput liquid chromatography and high-resolution mass spectrometer ...
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MtoZ Biolabs - Tumor-Associated Antigens 1 Screening Service

MtoZ Biolabs - Tumor-Associated Antigens 1 Screening Service

by:MtoZ Biolabs   based in, MASSACHUSETTS (USA)
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens by surface T cell receptors (TCRs). Most human T cells express the classical TCRs, which consists of TCRα and TCRβ chains co-expressed with CD3 chains (γ, δ, ε, and ζ). ...
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