MtoZ Biolabs - Model peptide-biomarkers-analysis - Peptide Biomarker Discovery & Validation Service
Biomarkers are measurable traits that serve as indicators of normal biological activities, disease processes, or pharmacological responses to therapeutic interventions. Peptides are particularly suitable as biomarkers due to their ability to circulate among various body compartments. Many disease processes can be inferred from the characteristic peptide profiles and pathological changes observed in different body fluids. Moreover, variations in peptide abundance associated with various diseases are detectable.
Two prevalent approaches to developing peptide biomarkers are pattern recognition and single/oligo biomarker assay. Pattern recognition does not require identifying the candidate biomarkers and relies solely on mass spectrometry's exceptional specificity and sensitivity to derive patient information. In contrast, the single/oligo biomarker assay is more effective as their expression levels can be verified across various biological samples. Mass spectrometry-based methods can accurately determine analyte concentrations and feature precise mass measurement and sequencing capabilities.
Lee, J. E. Genomics & Informatics. 2016.
To screen and validate peptide biomarkers, it is necessary to identify the peptides in a sample (qualitative analysis) and quantify their concentrations (quantitative analysis). Effective screening requires integrating both steps. Numerous analytical techniques are employed in biomarker detection, among which the combination of mass spectrometry and liquid chromatography (e.g., UPLC and nanoLC) stands out for its high resolution, sensitivity, throughput, and quantification capabilities.
MtoZ Biolabs employs the Thermo Fisher’s Orbitrap Fusion Lumos mass spectrometry system along with nanoLC chromatography for advanced peptide biomarkers analysis services.
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com