Scalable Manufacturing Services
Mesenchymal stem cells (MSC) are multipotent cells with regenerative, multidifferentiation, and immunomodulatory capacities. Expanding MSC for clinical purposes usually requires large cell dose, which demanding efficient cultivation platforms.
Conventional in vitro cell expansion is conducted in static planar culture system. Less efficient space utilization constrains the scale of cell expansion. These limitations impel MSC manufacturing toward three-dimensional culture systems operating under dynamic conditions providing an economic model in respect of consumables, labor, quality controls and facility costs.
The collaboration work of AventaCell and academic institutions have been successfully utilizing human platelet lysate (hPL) to expand MSC in multiple bioreactor systems (de Sure et al., 2017; A. Mizukami de al., 2018; de Sousa Pinto et al., 2019). It demonstrated applicability of hPL for scale-up MSC production in terms of maintaining cell reproducibility, stability and quality.