
Advancells - Stem Cell Therapy for Muscular Dystrophy
Muscular dystrophy is a group of disorders, characterized by progressive degeneration of skeletal muscles and muscle weakness. There are nine different types of dystrophies and all of them are associated with the faulty gene dystrophin that creates a defect in muscle protein, leading to progressive damage of muscle cells and tissue. Most of these muscular dystrophies are multi-system disorders with manifestations in different systems of the body, such as the cardiovascular system, gastrointestinal system, nervous system, endocrine system, etc. Thus, children with muscular dystrophy typically succumb to paralysis and eventually death in their early twenties due to respiratory failure and cardiac complications. In the majority of the cases, the symptoms are apparent in early childhood by the age of 3-5 years, when the child has difficulty in walking and controlling body movements.
Although conventional treatment options are limited, due to recent successful therapeutic benefits of stem cell therapy for muscular dystrophy treatment, proven in pre-clinical analysis; a keen interest has been developed in using stem cells for muscular dystrophies, with the hope that they are effective in regenerating muscular damage.
With extensive research these challenges are now comprehensible to therapeutic ventures resulting in new treatments of muscular dystrophy using autologous treatment/allogenic transplant for adipose-derived mesenchymal stromal cells treatment and bone marrow stromal cells treatment.
This new insight on the treatment of muscular dystrophy has helped in identifying the potential to overcome muscular dystrophy with stem cells, primarily using autologous stem cell transplant in form of hematopoietic stem cell transplant or mesenchymal stromal cells treatment.