OncoPeptTUME - Tumor Microenvironment Analysis
Profiling the Tumor Microenvironment: Using a genomics based approach to analyze the tumor microenvironment can provide unique insights beyond IHC and FACS methods. OncoPeptTUME deeply interrogates RNA-Seq data sets to produce high resolution mapping of the tumor microenvironment using proprietary cell type specific gene expression signatures. OncoPeptTUME provides a critical assessment of the inflammatory microenvironment that modulates T-cell infiltration and its anti-tumor activities to enable better prediction of treatment response and efficacy.
- Requires low sample input from FFPE or fresh frozen tissues compared to IHC or FACS
- High throughput and robust workflow at significantly lower cost than IHC and FACS
- Provides an accurate representation of the tumor microenvironment at a cellular, molecular and biochemical level
- Shorter analysis time with high information content and less variability in data
- Can be customized to fit cancer immunotherapy project needs and tailored to perform in preclinical and clinical settings
- Continuously updated to include new insights from cancer immunotherapy basic and translational research
- Streamlined pipeline for fast & scalable analysis
- Customized reporting
- Interactive reports
- Publication-ready figures
- Improve data interpretation with support from Medgenome’s team of experts
Pre-Clinical Applications
- Discover biomarkers for patient stratification
- High resolution mapping of gene expression in the tumor and stromal compartments
Clinical Applications
- Discover biomarkers for patient selection
- Monitor durability of response
- Accurate quantification of biomarkers before and after drug treatment
Post Approval Applications
- Analyze patient outcome
- Evaluation of drug resistance
- Discover novel drug targets to increase efficacy and reduce toxicity
- OncoPepTUME pipeline quantifies the relative infiltration of innate and adaptive immune cells (CD8+, CD4+, T cells, B cells, Treg cells, NK cells, Macrophages, Monocytes, Neutrophils) with proprietary immune cell type-specific gene expression signatures.
- Identify biomarkers for patient selection, predict likelihood of response to checkpoint inhibitor therapies and monitor durability of response.
Ordering and Data Delivery
MedGenome`s customer portal allows for easy sample submission and sample tracking during lab processing. Data QC, raw data and interactive analysis reports are delivered securely through customer portal.