Viral Vector Process Development and Optimization

With over 60 products manufactured, we offer extensive experience transferring in, establishing, and optimizing viral vector processes. Development of cell culture processes to support: Suspension: 50L to 2000L single-use bioreactors. Adherent: Flatstock and iCELLis® platforms.

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viral vector

preclinical product

clinical development

Purification capabilities:

Platform purification processes offered for all vector types
Single-use / non-product contact equipment
Depth, TFF and other filtration methods for harvest and concentration
Broad range of chromatography solutions: Affinity, SEC, IEX, and HIC
Viral inactivation and clearance studies
Optimization as needed for:
- Increasing yield / recovery
- Full capsid separation
- Specific purity requirements

Available services:

Customized transfection and infection parameters as necessary
Multiple 2L and iCELLis® NANO bioreactors for bioreactor development and optimization
Multiple 50L and 200L bioreactors for scale up and pre-clinical material production
ambr® 15 for DoE studies and rapid development
Custom media optimization, production, sourcing, and testing
Manifolding for plate-based development
Partitioning studies

Viral Vector Process Development and Optimization

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