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AlloSeq - Model HCT - High Sensitivity Chimerism Testing Software
Every minute of laboratory time is valuable. AlloSeq HCT can help you save time with a simple workflow and powerful analysis software, all while achieving high sensitivity chimerism monitoring. Engraftment monitoring (chimerism) testing evaluates the success of a hematopoietic stem cell transplant by measuring the relative ratio of the recipient and the donor cell population in the recipient’s post-transplant specimen. Engraftment monitoring may assist in detecting disease relapse or graft failure.
AlloSeq HCT is an NGS-based solution enabling precise measurement of engraftment following hematopoietic stem cell transplant for research applications
- Simple, streamlined assay (one multiplexed reaction per sample)
- Targets 202 bi-allelic SNPs across 22 autosomes
- Validated for use on Illumina MiSeq
- Streamlined workflow with minimal hands-on time (3 hrs)
- Sample to result in less than 24 hours
- Highly sensitive (0.36% limit of detection)
- Accurate, precise, and reproducible results
- User-friendly AlloSeq HCT software features automatic determination of informative loci, chimerism calculation, and results tracking
- Able to determine up to 3 genomes in a single sample; useful for double cord blood transplants
The AlloSeq HCT assay enables the amplification and sequencing of 202 single nucleotide polymorphisms (SNPs) across all autosomal chromosomes. The AlloSeq HCT software automatically calculates % recipient and donor DNA in post-transplant samples.