Protein Discovering Novel CRISPR Systems

Our protein discovery process involves an in-silico analysis from exclusive metagenomic databases and machine learning algorithms to search for CRISPR systems. High-throughput in vivo screening is used to identify the CRISPR protein characteristics and function. Together, the newly identified Cas proteins create a diverse toolkit that enables new CRISPR applications.

We have identified Cas enzymes that have unique properties including increased temperature stability, faster reaction kinetics, alternative PAM sequences resulting in more flexible targeting and smaller protein size which opens up new cell delivery options.

These properties can be leveraged resulting in faster and more sensitive molecular diagnostic tests and provide efficient delivery of DNA inserts for cell and gene therapies.