Dsr ??? Potential New Treatment for Diuretic-Resistant Fluid Overload Due To Heart Failure - Video

Direct Sodium Removal (DSR®) therapy is Sequana Medical's novel and proprietary approach in development for the management of fluid overload due to heart failure.

The sodium concentration in patients with fluid overload is in balance but there is too much sodium and too much fluid in the body. The DSR approach removes excess sodium in patients with residual renal function leading to lower sodium concentration in the body. As a result, the body acts to restore the sodium concentration in the body by eliminating fluid through urination and osmotic ultrafiltration, resulting in a sustained level of fluid loss.

DSR therapy uses the peritoneal cavity for the removal of sodium via diffusion. To do this, a “sodium-free” solution (the “DSR infusate”) is administered to the peritoneal cavity and allowed to dwell for a pre-defined period. During this time, sodium diffuses from the body down a steep diffusion gradient into the DSR infusate. The blood circulation keeps the effective blood sodium concentration high thereby preventing hyponatremia. The DSR infusate and the extracted sodium are then removed, resulting in a removal of sodium from the body. The body responds by eliminating the associated fluid via osmotic ultrafiltration (the movement of water, together with sodium, from the bloodstream to the peritoneal cavity) and/or urination.