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Preclinical Modeling Product Applications Available In Slovakia
3 applications found
In vivo soft tissue imaging for morphological characterization. 2D and 3D imaging can be performed quickly and easily for preclinical model ...
ByAspect Imaging Ltd. based in Nashville, TENNESSEE (USA)
Functional ultrasound (fUS) imaging is emerging as a powerful tool in neuropharmacology to study the effects of drugs on brain activity. Unlike fMRI, fUS offers increased sensitivity and compatibility with awake animal models, providing an unbiased view of drug interactions with neural substrates. Recent studies by Theranexus have utilized fUS to observe the hemodynamic response to different pharmacological interventions, such as the combination of donepezil and mefloquine, which target acetylcholinesterase ...
ByIconeus based in Paris, FRANCE
Accurate ADME-Tox profiling of preclinical drug candidates remains a challenge. Preclinical ADME-Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity) studies are pivotal to predicting human response. However, approximately 30% of drugs fail during human clinical trials due to adverse reactions despite promising preclinical study results, and another 60% fail due to lack of efficacy. As companies broaden the modality toolbox with novel drug delivery ...
ByEmulate based in Boston, MASSACHUSETTS (USA)