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Proteomics Product Applications In Europe
10 applications found
Many key protein functions require the protein to undergo a post-translational modification (PTM), examples ranging from phosphorylations and glycosylations to histone modifications and ubiquitinations. HuProt human proteome microarrays can be used for profiling the targets of enzymes producing PTMs and have been used in studies of phosphorylation, glycosylation, sumoylation, ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
The concept behind protein arrays is the immobilisation of sets of proteins, up to very large numbers, on solid supports, to perform miniaturised, multiplexed binding assays with a variety of potential ligands or interactants (see powerpoint presentation on right). HuProt v4 human proteome arrays as used at CPA comprise full length human proteins, many of which will retain their native conformation. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Profiling of nucleic acid binding on HuProt human proteome microarrays can reveal interactions with the largest collection of individual human proteins available on a single slide. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Determine the interactome of your favourite protein. HuProt arrays provide a primary platform for screening proteins for binary interactions with the world's largest collection of human proteins immobilised on a single microarray. Over 20,000 potential interactions are assessed in a single experiment. Array screening facilitates detection of interactors with low abundance in cellular systems. Combined with other data, the array output can confirm known interactors and discover new ones, illuminating the protein ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Explore interaction profiles and identify off-target binding. Most drugs in common use are small organic molecules which interact functionally with proteins, either acting as ligands for receptors, inhibiting enzymes or blocking protein interactions, etc. Their activities have generally been established by specific cellular and molecular assays to determine mode of action. While frequently well tolerated, side-effects are nevertheless commonplace and can be the result of unexpected interference with unintended ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Comprehensive antibody reactivity profiling: validate specificity, identify cross-reactions. The issue of antibody cross-reactivity is one that has often been often overlooked or sidelined in the past, with typical antibody QC involving evidence of binding to the intended target, while neglecting potential cross-reactivity. In recent years, however, many examples have come to light where poor validation of antibodies has led to misleading or erroneous conclusions for assays in which they are used as reagents, due ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Discover autoantigens in autoimmune diseases, delineate new candidate biomarkers. Autoantibodies are present in the blood of all healthy individuals. However, when directed at high levels against protein targets in specific tissues, autoantibodies can be a major cause of autoimmune diseases. They are also important biomarkers for diagnosis of these conditions. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
FluidFM® for Neuroscience - revise your approach of single neurons manipulation!A key feature of neurons is that they communicate with each other and with their environment. Nevertheless, analyzing and understanding these interactions at a single cell level remains a key challenge in cellular neurobiology. By uniting the best features of microfluidics and force microscopy and using different force-controlled probes, FluidFM provides an ideal tool for researchers with a wide range of methods; from ...
ByCytosurge AG based in Glattbrugg, SWITZERLAND
Introducing single-cell biopsy The novel non-invasive method for single-cell omics The novel method that keeps your cells alive during biopsy from single cells Single-cell omics addresses cellular heterogeneity head on by isolating and analyzing molecular components from individual cells. While many of the existing technologies rely on cell lysis — single-cell biopsy is the only non-invasive single-cell analysis method that allows researchers to take transcriptome snapshots of a ...
ByCytosurge AG based in Glattbrugg, SWITZERLAND
FluidFM® for Virology - Get a unique control over your single virion-single cell in-vitro experiment! Typically, viral infections are studied in bulk experiments where many cells in culture are exposed to the virus simultaneously, making it difficult to study single virus entry events or the spread of the viral infection between individual cells. With the gentle, micro-channeled, and force feedback-controlled FluidFM Probes, single virions can be deposited onto selected cells allowing unprecedented control to ...
ByCytosurge AG based in Glattbrugg, SWITZERLAND