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Drug Release Delivery Product Applications In Spain
5 applications found
The defense mechanisms observed in the eye (epithelium, tear flow and blinking reflex) hamper the drug penetration into deeper layers of the eye. The use of modified liposomes with mucoadhesive polymers and a specific lipid formula helped in overcoming these surface obstacles and reaching target areas as the conjunctival ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Drug delivery in the retina is normally performed through intravitreal injection but it is only suitable for compounds fitting a list of criteria like long half-lives. Decoration of engineered exosomes derived from retinal cells with hyaluronan binding peptides is a very effective alternative to intravitreal injection. Hyaluronan can be found in high concentrations in the vitreous of the eye, and thus, this strategy enhances the penetration and uptake from retina ...
ByNanovex Biotechnologies based in Llanera, SPAIN
The delivery of therapeutical compounds such as RNA drugs into the brain presents the challenges of RNA preservation and the crossing of the blood brain barrier. Exosomes loaded with the specific siRNA sequences and marked with the neuron specific RVG peptide show specific accumulation in neurons, microglia and oligodendrocytes in the brain, effectively reducing genetic expression. This is a potential approach for brain diseases like Alzheimer, while reducing side effects due to unspecific tissue ...
ByNanovex Biotechnologies based in Llanera, SPAIN
Glaukos is developing multiple micro-invasive, bioerodible, sustained-release drug delivery platforms designed to be used in the treatment of various retinal disease, including age-related macular degeneration (AMD) and diabetic macular ...
ByGlaukos Corporation based in San Clemente, CALIFORNIA (USA)
The trespassing of the blood brain barrier is a challenge for the treatment of central nervous diseases such as Alzheimer, Parkinson, stroke, or cancer (glioma). The endothelium shows tight junctions and specialized transporters which limits the bioavailability of drugs in the central nervous ...
ByNanovex Biotechnologies based in Llanera, SPAIN