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Bone Resorption Articles & Analysis
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Structure of Matrix Metalloproteinase (MMP) Family In vertebrates, the MMP family consists of 28 members, at least 23 of which are expressed in human tissues, 14 of which are expressed in the vascular system. MMPs are usually classified into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs based on their substrates and the organization of their ...
Introduction to OsteoporosisOsteoporosis is a systemic multi-causal skeletal disease that is prone to fractures due to changes in systemic bone mass and microstructure of bone tissue, resulting in increased bone fragility. Osteoporosis is a type of disease that is difficult to cure. According to the etiology, it can be divided into primary osteoporosis, secondary osteoporosis and idiopathic ...
ABSTRACT Previous subgroup analyses from the ACTIVE trial in women with postmenopausal osteoporosis (NCT01343004) using three-dimensional (3D)-processing of dual X-ray absorptiometry (DXA) scans indicated greater increases in total hip cortical volumetric bone mineral density (Ct.vBMD) and estimated indices of hip strength following 18 months of abaloparatide (ABL) versus placebo or ...
INTRODUCTION The goal of the implant surgeon is to place the implant in the ideal position, to support the prosthesis for the best long term prognosis, while managing important anatomical landmarks. With the aid of Cone Beam CT scans the implant surgeon is able to evaluate, in three dimension, the ridge, important anatomy, as well as pre-plan implant placement in the most ideal position. ...
Digital dentistry refers to the use of dental technologies or devices that comprises digital or computer-controlled factors to raise out dental processes as an alternative than using mechanical or electrical tools. The use of digital dentistry can make carrying out dental methods more environmentally friendly than using mechanical tools, each for restorative as diagnostic purposes. 'Godfather' ...
Alendronic acid or Alendronate Sodium is a bisphosphonate drug that inhibits osteoclast-mediated bone resorption. Biphosphates work by binding to the bone and preventing calcium from being removed by osteoclasts. This drug is used to prevent and treat osteoporosis as well as several other bone diseases. Alendronate Sodium is sold as tablets or solutions, alone or in combination with Vitamin D. ...
Rab3 proteins are a subfamily of GTPases, known to mediate membrane transport in eukaryotic cells and play a role in exocytosis. Our data indicate that Rab3D is the major Rab3 species expressed in osteoclasts. To investigate the role of Rab3D in osteoclast physiology we examined the skeletal architecture of Rab3D-deficient mice and found an osteosclerotic phenotype. Although basal osteoclast ...