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Drug Discovery Process Articles & Analysis
23 articles found
In the realm of drug discovery, kinase screening services have emerged as a pivotal tool for understanding complex cellular signaling pathways and identifying potential therapeutic targets. Kinases are enzymes that play a crucial role in regulating cellular functions by adding phosphate groups to proteins, a process known as phosphorylation. This post-translational modification can activate or ...
In this white paper, Predictive Oncology (POAI) highlights a recent successful project in partnership with the University of Michigan Natural Products Discovery Core (NPDC) through the ACE program. The ACE program supports academic researchers in their early drug discovery and development initiatives by providing access to the POAI proprietary active machine learning platform and ...
Hello, and welcome back to the Colorful Researcher’s blog. In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. In his post, Peter explained how small instruments like BUCHI’s Glass Oven G-300 are great for working with small ...
ByBUCHI
Understanding the metabolic stability of potential drug candidates is paramount in the realm of pharmaceutical development. S9 metabolic stability assays provide critical insights into how a compound behaves within biological systems, especially concerning its metabolism, stability, and overall pharmacokinetics. At the core of S9 metabolic stability is the S9 fraction, which is a liver extract ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. Central to this phase is the use of appropriate disease models, which are essential for understanding the ...
Understanding the complex world of drug discovery and development necessitates familiarity with key players in cellular communication. A pivotal group in this arena is G Protein-Coupled Receptors (GPCRs). These receptors play a crucial role in transmitting signals across cell membranes, significantly influencing numerous physiological processes. Consequently, GPCRs have become a central focus in ...
Introduction Microarray printing technology has revolutionized the field of genomics and proteomics, and its application in glycobiology is no exception. Glycobiology, the study of carbohydrates and their biological functions, relies heavily on the ability to analyze large-scale carbohydrate interactions. Microarray printing in glycobiology enables the precise and high-throughput analysis of ...
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be ...
In recent years, the field of biotechnology has seen groundbreaking advancements, with the integration of artificial intelligence (AI) into gene editing and therapy. AI-driven technologies have transformed the way we approach genetic modification and treatment, offering unprecedented opportunities for precision medicine and therapeutic interventions. One of the most significant applications of ...
In recent years, the field of biotechnology has seen groundbreaking advancements, with the integration of artificial intelligence (AI) into gene editing and therapy. AI-driven technologies have transformed the way we approach genetic modification and treatment, offering unprecedented opportunities for precision medicine and therapeutic interventions. One of the most significant applications of ...
In the vast and ever-evolving field of medicine, the discovery of new drugs has been a critical pursuit, offering hope and relief to countless individuals suffering from various ailments. The process of drug discovery is a complex and multifaceted endeavor, involving the integration of diverse scientific disciplines, including biology, chemistry, and computational science. At the heart of this ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
Molecular docking, a critical component of structure-based virtual screening, plays a pivotal role in the field of drug design by predicting the binding interactions between small molecules and proteins. This article explores the various approaches, software tools, and techniques employed in molecular docking and highlights their potential in accelerating drug discovery. The Importance of ...
In the dynamic realm of drug discovery, the pursuit of innovative and effective treatments for diverse diseases demands groundbreaking approaches that can expedite the drug development lifecycle. Amidst these endeavors, Computer-Aided Drug Design (CADD) has emerged as a transformative methodology, harnessing the power of computational tools and simulations to predict, understand, and optimize the ...
In the field of biomedical research, immortalized cell lines have proven to be invaluable tools for a wide range of studies. These cell lines, derived from primary cells, possess the unique ability to undergo continuous division, providing researchers with a sustainable and consistent source of cells for experimentation. Additionally, immortalized cell lines have the advantage of maintaining the ...
In the fast-paced realm of drug discovery, scientists constantly seek innovative approaches to efficiently and cost-effectively identify potential drug candidates. Virtual screening, a breakthrough computational technique, is poised to transform the pharmaceutical industry. In this article, we delve into the world of virtual screening and explore its remarkable potential to revolutionize drug ...
It was great to be back in person at the 2022 BIO International Convention this year. It came as no surprise to us at Recursion that artificial intelligence (AI) and machine learning (ML) were hot topics at the conference, with more than half a dozen sessions exploring how these technologies are driving digital transformation in biopharma. We heard from leaders who are applying AI at ...
Insilico Medicine announced the nomination of a novel preclinical therapeutic candidate for treating COVID-19, designed using the generative chemistry AI platform Chemistry42. The new drug candidate is a 3CL protease inhibitor unique from existing drugs in its class because it can be rapidly produced. While this nomination is a potentially important development for the ongoing COVID-19 pandemic ...