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Antigen Based Articles & Analysis
9 articles found
Target Selection: The initial step in ADC development is identifying an appropriate target. Tumor-associated antigens (TAAs) are typically selected based on their expression in cancer cells versus normal tissues. ...
In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). ...
On the other hand, adjuvants can alter the physical properties of antigens, leading to slower release of antigens in the body and prolonging the interaction between antigens and immune cells. ...
Here, using a genetic timestamping system in mice, we show that persistent PCs accrue in bone marrow at an approximately constant rate of one cell per hour over a period spanning several weeks after a single immunization with a model antigen. Affinity-based selection was evident in persisting PCs, reflecting a relative and dynamic rather than absolute affinity ...
The following publication describes a study developing the ROP-TB antigen for both in vitro IGRA-based TB diagnosis, as well as the in vivo skin test for TB diagnosis in both humans and cattle. ...
The peptide can be specifically cleaved by metalloproteinases (MMP) and released at the site of the tumor lesion, enabling greater precision of antigenic peptide epitope delivery based on the antibody's directedness. ...
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? ...
We evaluated a novel, magnetic-bead-based histo-blood group antigen assay for the recovery of low numbers of norovirus particles. ...
Many HIV-1 envelope-based synthetic peptides behave as antigenic mimics of linear or conformational epitopes generated in vivo in infected subjects, meaning they can be used as immunogens for antibody induction in appropriate animal models or as antigens in Enzyme-Linked Immunosorbent Assay (ELISA). These peptides are linear or branched, single ...