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Antigen Binding Articles & Analysis
48 articles found
These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
They work by binding to foreign molecules, known as antigens, which can be proteins, polysaccharides, or other substances found on pathogens or abnormal cells. By binding to these antigens, antibodies can neutralize pathogens directly or mark them for destruction by other immune cells. ...
This specificity is achieved by linking a radioactive isotope to a monoclonal antibody or small molecule that targets specific cancer antigens. When administered, the RDCs selectively bind to the cancer cells, allowing for localized delivery of radiation. ...
Single-domain antibodies consist of a single polypeptide chain that retains the ability to bind specifically to antigens. Unlike traditional antibodies, which are composed of heavy and light chains, these smaller fragments are typically around 15 kDa in size. ...
For example, their molecular weight, volume and polarity are much higher than those of small molecule drugs, which make the pharmacokinetic properties of mAbs different. The specific binding between the mAb and the target can also greatly affect the elimination of the mAb drug. ...
In biomedical research, antibodies are a powerful tool used in the detection and quantification of target antigens. However, a comprehensive understanding of the antibody requires knowledge of its amino acid sequence, which can be achieved through antibody sequencing.Antibody sequencing is a nucleic acid sequencing process that determines the nucleotide sequence of the gene ...
They have the advantages of small size, high stability, and good penetration, and therefore have a wide range of application prospects in the fields of clinical treatment, diagnostic reagent development, etc.Characteristics of NanobodiesThe size of nanobodies usually ranges between 10-15kDa, which is only 1/10 of the size of regular antibodies. Their unique ...
In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). Antibodies, also known as immunoglobulins, are proteins produced by B-cells, a type of white blood cell. They recognize and bind to specific antigens, ...
Their monoclonal antibodies, linkers, linker-cytotoxin molecules, and newly introduced antigenic epitopes may all have immunogenicity. This makes the immune response induced by ADC drugs more complex. ...
The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. ...
They can trigger an immune response in the human body by recognizing and binding to specific antigens, thereby combating pathogens. However, to develop monoclonal antibodies with high specificity and affinity, sequencing of the antibody's variable region is required. Sequencing the variable region of a monoclonal antibody refers to decoding the genetic ...
At present, peptide drugs have shown broad application prospects in the treatment of tumors, hepatitis, diabetes, and AIDS.Antibody-Based TherapyAntibodies are proteins produced by the immune system that can bind to specific markers on cells or tissues. In cancer treatment, monoclonal antibodies (mAbs) can directly kill cancer cells, prevent the development of tumor blood ...
This epitope can be a unique area in the target antigen with specificity, allowing the antibody to accurately recognize and bind to it; or it can be those areas with cross-reactivity, allowing the antibody to interact with other proteins with similar sequences.Determine the Type of ExperimentThe types of experiments suitable for antibodies are often related to ...
Mapping Epitopes and Paratopes Through antibody sequencing, we can determine epitopes (binding sites of antigens) and paratopes (binding sites of antibodies), reveal information that helps to draw epitope maps, guide antibody design, and paratope variations, which can enhance the specificity of antibody drugs. ...
To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.Definition of Antibody ActivityThe activity of an antibody drug usually refers to its ability to bind to the target antigen and how it affects the target in a biological function, such as neutralizing viruses, killing tumor cells, or regulating immune ...
The constant region of an antibody is usually at the bottom of the molecule, close to the tail of the antibody, corresponding to the variable region of the antibody, which is responsible for recognizing and binding to antigens. The constant region usually contains a set of constant amino acid sequences, which determine the class (such as IgG, IgA, IgM, etc.) and ...
These therapeutic antibodies aim to specifically target antigens on the surface of cells and bind to them, leading to acidic reactions that result in the destruction of target cells. ...
The antibody component specifically targets surface antigens on specific cancer cells, while the drug component is responsible for killing these bound cancer cells. ...
Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages. ...
Among them, the specific interaction between receptors and ligands can be used to target ligand-labeled liposomes to organs, tissues or cells containing ligand-specific receptors, and the binding of receptors and ligands can promote lipid Internalized into cells. Monoclonal antibodies can also be coupled with liposomes to construct immunoliposomes (or affinity liposomes), and the ...