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Antigen Peptide Articles & Analysis
13 articles found
Compared to traditional whole-virus or protein vaccines, peptide vaccines possess the following unique advantages: l High designability: Researchers can screen immunogenic short peptide segments based on pathogen protein sequences as vaccine antigens.l Higher safety: Peptides do not contain pathogenic components, will not cause infection, and ...
What Are Synthetic Peptides? Peptides are short chains of amino acids linked by peptide bonds and are crucial in many biological functions. ...
The Unique Value and Challenges of Peptide Antigens in Antibody DiscoveryChoosing the right antigen is crucial in antibody discovery. ...
Antimicrobial peptides, also known as host defense peptides, serve as frontline warriors in our immune system. ...
However, many of these formulations carry a high risk of causing allergies or autoimmune reactions. Peptide vaccines are increasingly seen as an economically efficient and safe approach to circumvent this issue.Peptide Vaccine DevelopmentThe vaccine development process is a challenging multi-step process: Antigen selection→Epitope selection→Adjuvant ...
In this paper, CMV antigenic peptide epitopes are employed, with peptides that have been proven to be functional and more generic for CMV-CTL. ...
T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those expressed by cancer cells. αβ T cells are the effector cells of adaptive immunity, which exert cytotoxicity in a major histocompatibility complex (MHC)-restricted manner. ...
Using the power of large data and advanced computational methods, researchers can identify peptides on the surface of tumor cells and can target "peptide-centric" chimeric antigen receptors (PC-CARs): a new design of T cells that stimulates the immune response to eliminate tumors. ...
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? ...
Recently, researchers at Notre Dame University have identified specific features of the reaction of two distinct peptide antigens to a T-cell receptor (TCR), which provides new clues to optimizing molecular structure for the development of immunotherapy of cancer cell research. ...
Chimeric antigen receptor T-cells (CAR-T) are one of the first clinically approved therapies to take full advantage of the most significant advancements in immunology and genetic engineering. The resulting therapeutics have been shown to produce remission rates exceeding 80% in patients with CD19+ B-cell lymphoma, making them nothing short of remarkable [1]. Unfortunately, CAR-T cells seem ...
Although the best-defined function of type II major histocompatibility complex (MHC-II) is presentation of antigenic peptides to T lymphocytes, these molecules can also transduce signals leading alternatively to cell activation or apoptotic death. ...
Many HIV-1 envelope-based synthetic peptides behave as antigenic mimics of linear or conformational epitopes generated in vivo in infected subjects, meaning they can be used as immunogens for antibody induction in appropriate animal models or as antigens in Enzyme-Linked Immunosorbent Assay (ELISA). These peptides are linear or ...