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Bioinformatics Method Articles & Analysis
7 articles found
It comprehensively analyzes and identifies transcripts in cells or tissues through high-throughput sequencing technology, and quantitatively and functionally analyzes them through bioinformatics methods to reveal gene expression regulatory networks and related biological functions. ...
Strategies such as sample fractionation, enrichment techniques, or targeted extraction methods are employed to mitigate the complexity of samples and enhance the detection of low-abundance metabolites. ...
Therefore, decoding information about modifications that affect sequence or structural changes is increasingly important. Methods for detecting RNA modifications Currently, most methods used to detect RNA modifications fall into three categories: high-throughput whole-transcriptome sequencing technologies, mass spectrometry methods, and ...
Introduction of HPLC-MS/MS-based Proteomics Technology The development of high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) based proteomics technology mainly depends on the liquid chromatography-mass spectrometry equipment, sample separation and preparation technology, identification, as well as bioinformatics. At present, shotgun ...
Integrating suitable bioinformatics pipelines and NGS-based approaches is important for the accurate genotyping of HLA and mapping complete HLA regions. The appropriate bioinformatics approach depends on the sample preparation method and the type of sequencing platform. ...
Usually, targeted Illumina or 454 reads of up to a few hundred nucleotides are HTS methods to 16S rRNA sequence evaluation, each focusing on uniquely identifiable variable gene areas that can be utilized as unique microbial identifiers. ...
Outliers were removed by the ROUT method (Q = 1%) and data were analyzed using a nonparametric Kruskal–Wallis test with Dunn’s multiple comparison test. ...