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Cell Line Development Articles & Analysis
16 articles found
Among the various production systems available, Chinese Hamster Ovary (CHO) cells have emerged as a gold standard for monoclonal antibody production, and specialized services have been developed to streamline this process. ...
Adenoviruses are a group of viruses that have gained significant attention in recent years, particularly in the fields of gene therapy, vaccine development, and cancer treatment. With their ability to deliver genetic material into cells effectively, adenoviruses serve as valuable vectors in various biomedical applications. ...
Target Selection: The initial step in ADC development is identifying an appropriate target. Tumor-associated antigens (TAAs) are typically selected based on their expression in cancer cells versus normal tissues. ...
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. This process involves the integration of specific DNA sequences into precise loci within the genome, allowing scientists to explore gene function, model diseases, and ...
Traditional methods often fall short when trying to establish immortal cell lines from certain species, such as chickens, monkeys, dogs, and even human T cells. ...
The Latest Technological Advances in Antibody Discovery1. Single B Cell Isolation and SequencingThe isolation and sequencing of single B cells can help us gain a deeper understanding of the diversity and specificity of B cells. ...
However, it is not easy to develop a stable cell line that maintains ideal growth and productivity characteristics. ...
To address this limitation, researchers have developed CRISPRa stable cell lines, which are engineered to constitutively express the components necessary for gene activation. ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to ...
Mature miRNAs assemble into RNA-induced silencing complex (RISC), guide the complex to target messenger RNAs (mRNAs), and regulate their expression either by cleavage of target mRNA or by translation inhibition. Creative Biogene is developing stable cell lines overexpressing human / mouse/ rat miRNA precursors covered in the current miRbase. Our ...
Its advantages of high throughput and rapidity are very suitable for large-scale drug development and testing. FC can detect multiple parameters on the cell surface. ...
A central facet of this process involves the development of stable cell lines that are capable of producing these vital products in abundance and with consistency. ...
One such venture is the creation of Inducible Expression Stable Cell Line (IESCL) development. IESCL signifies a consolidated methodology designed to explore the potentialities of modulated gene expression. ...
Such examples are the DF-1, AGE1, QOR and EB66 cell lines, used for the development and production of vaccines. Nuvonis’ novel suspension avian cell line CCX.E10 The recently introduced novel suspension avian cell line CCX.E10 ...
ByNuvonis
Stable isotope labeling with amino acids in cell culture (SILAC) Stable isotope labeling with amino acids in cell culture is an in vivo metabolic labeling method, which is highly accurate and reliable for both absolute and relative protein quantification. The isotope of Lys (13C or 15N) and Arg (13C or 15N) are added to the cell medium lacking ...
The growing pipeline of cell and gene therapy therapies has led to an increase in demand for gene delivery vehicles such as plasmid DNA (pDNA), messenger RNA (mRNA) and viral vectors. They can be used as stand-alone treatments or can be used as starting materials required for further processing of cell and gene therapeutics. When used as starting materials, ...