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Drug Dissolution Articles & Analysis
8 articles found
These biocompatible, water-swollen structures are formed with the incorporation of drug-loaded microspheres or nanoparticles. Their porous nature allows the sustained release of drugs, enhancing therapeutic efficacy. ...
The evolution of these therapies accelerated with the understanding that STEMI is caused by occlusive thrombus compromising flow in an epicardial coronary artery1,2. Initially, drug-based dissolution of the occlusive thrombus was the only therapeutic modality, but this has been superseded by mechanical recanalization and breakdown with wires and balloons with ...
The main areas of application for sucrose-based polymers focus on drug release formulations. In the field of drug release, the hydrophilicity of drug carrier materials is an important factor affecting drug efficacy. The so-called drug efficacy refers to the following effects after drug use: ...
The compatibility of the main drug and the excipients should be studied. When screening and researching drugs with new chemical structures, attention should be paid to the investigation of the interaction between the main drug and the excipients. The excipients should have stable properties with no physiological activity, no influence on the ...
Body and cap tightness, water vapor permeability Airtightness and water vapor permeability are two important technical indicators of medicinal plastic bottles, and they play a crucial role in drug stability. Quality Assurance System Auditing suppliers has become an essential part of purchasing plastic bottles. ...
The hydrophilic group of β-CD can improve the solubility, dissolution rate and bioavailability of the drug after the inclusion of the poorly soluble drug, and the hydrophobic group can control the release rate of the drug after forming an inclusion complex with the water-soluble drug. ...
Therefore, a disintegration test should be carried out to make sure that a drug is released within a specified time. The disintegration time of a drug is of great significance to the bioavailability of the drug. In the case of slow disintegration where the drug is discharged in its original form without disintegration, the ...
The chemical structure of the hydrogels was confirmed by means of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). In all cases, drug dissolution analysis showed that the active agent was released at a slower rate with hydrogels that contained acrylic acid.Keywords: drug dissolution, hydrogels, ...