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Genome Structural Articles & Analysis

18 articles found

Fosmid Library Construction: A Comprehensive Overview

Fosmid Library Construction: A Comprehensive Overview

Fosmid libraries represent a pivotal advancement in the field of genomics and molecular biology, offering a robust method for genomic cloning and analysis. ...

ByCreative Biogene


NGS Library Preparation Kits: A Key Component in Next-Generation Sequencing

NGS Library Preparation Kits: A Key Component in Next-Generation Sequencing

Next-Generation Sequencing (NGS) has revolutionized genomics, providing unprecedented insights into the structure and function of genomes, transcriptomes, and epigenomes. ...

ByCreative Biogene


Sequencing Depth, Coverage and Read Types for NGS   

Sequencing Depth, Coverage and Read Types for NGS  

The detailed point is to sequence the unknown genome sequence, and use bioinformatics analysis means to splice and assemble the sequence, so as to obtain the map of its genome. ...

ByCD Genomics


Amino Acid Sequence Analysis and Its Applications

Amino Acid Sequence Analysis and Its Applications

Prediction of Functional and Structural Domains Identifying known functional or structural domains using databases and tools (such as Pfam, SMART, InterPro, etc.). ...

ByMtoZ Biolabs


Karyotype Analysis for Rare Disease

Karyotype Analysis for Rare Disease

Many rare diseases have obvious manifestations of chromosomal structural abnormalities, making it a strategy to determine the cause of diseases from a macroscopic perspective of genetics. ...

ByProtheragen


Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances

Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances

What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, including the human ...

ByCD Genomics


The Molecular Microbiology of SARS-CoV-2: Detection Methods and Infection Mechanism

The Molecular Microbiology of SARS-CoV-2: Detection Methods and Infection Mechanism

HCoVs are categorized into four genera depending on sequence comparisons of viral genomes: alpha, beta, gamma, and delta coronaviruses. SARS-CoV-2 is a genetically linked beta coronavirus of another bat coronavirus named BatCoV RaTG13 and SARS-CoV-1. ...

ByCD Genomics


The Methods of Whole Genome Sequencing

The Methods of Whole Genome Sequencing

Overview of Whole Genome Sequencing The genome of each individual organism contains its entire genetic information. ...

ByCD Genomics


Study on Partial Glycoprotein of Feline Herpesvirus Type 1

Study on Partial Glycoprotein of Feline Herpesvirus Type 1

In addition to often invading the respiratory system, it can also infringe on the reproductive system, nervous system, conjunctiva and embryos. FHV-1 Genome Structure and Encoded Glycoproteins FHV-1 is a double-stranded DNA virus with an envelope. The full genome sequence is 126-134 kbp, and the GC content in the base is about 50%. Its ...

ByCreative Diagnostics


Applications of Microbial Whole Genome Sequencing

Applications of Microbial Whole Genome Sequencing

They are generally divided into fungi, actinomycetes, bacteria, spirulina, rickettsia, chlamydia, mycoplasma and viruses. Microbial whole genome sequencing is an important tool for mapping genomes of novel organisms, finishing genomes of known organisms, or comparing genomes across multiple samples. Sequencing the entire ...

ByCD Genomics


Long Read Sequencing Helps HLA Typing

Long Read Sequencing Helps HLA Typing

Based on long-read sequencing technology, whole human genome sequencing can accurately develop the genetic variation of DNA sequences between samples and reference genome or between individuals, such as structural variation (SV) and copy number variation (CNV), by using the obtained 10~20kb long reads to compare with the reference ...

ByCD Genomics


Long Read Sequencing Fills in the Missing Pieces of Genomics

Long Read Sequencing Fills in the Missing Pieces of Genomics

Long read sequencing has great application in the direction of de novo genome sequencing and resequencing, especially to improve the accuracy of detecting repeat regions, structural variants, as well as complex regions. Researchers used long read sequencing to produce haploid human genome assembly, populating multiple gaps in the reference ...

ByCD Genomics


Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment

Using AI to Fight a Pandemic: Insilico Medicine Announces Novel Preclinical Candidate for COVID-19 Treatment

There is an insightful technical report by Innophore, summarizing information about the coronavirus: its structure, active sites, sequence data, and so on. While showing similarities to beta coronaviruses found in bats, the specific coronavirus behind the COVID-19 pandemic is genetically different from other coronaviruses such as the previously known Middle East respiratory ...

ByInsilico Medicine


Back to blog Federated Architecture in Genomics

Back to blog Federated Architecture in Genomics

Genome initiatives spearheaded by burgeoning numbers of data custodians such as Genomics England (GEL), a Lifebit customer, leverage technological advances to amass large volumes of patient data. ...

ByLifebit


Seven technologies to watch in 2022

Seven technologies to watch in 2022

Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers Karen Miga at the University of California, Santa Cruz, and Adam Phillippy at the National Human Genome Research Institute in Bethesda, Maryland, launched the Telomere-to-Telomere (T2T) consortium in 2019. ...

ByAtlasXomics Inc.


Introduction to AAV as a Gene Therapy Vector, Part 1

Introduction to AAV as a Gene Therapy Vector, Part 1

Second, cellular machinery translates AAV’s viral genome into proteins which assemble into a viable viral shell with a copy of the viral genome packaged inside it. ...

ByDyno Therapeutics


Complexity metrics for ontology based information

Complexity metrics for ontology based information

Ontologies are used in service matching and dynamic web service composition, and are heavily used in bioinformatics and genomics to characterise the structure of living things. Our research focuses on complexity metrics for ontologies. ...

ByInderscience Publishers


Morphology, genome sequence, and structural proteome of type phage p335 from lactococcus lactis

Morphology, genome sequence, and structural proteome of type phage p335 from lactococcus lactis

Morphologically, P335 resembled the L. lactis phages TP901-1 and Tuc2009, except for a shorter tail and a different collar/whisker structure. Its 33,613-bp double-stranded DNA genome had 50 open reading frames. Putative functions were assigned to 29 of them. Unlike other sequenced genomes from lactococcal phages belonging to this species, P335 ...

ByAmerican Society for Microbiology (ASM)

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