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Immune Based Articles & Analysis
17 articles found
The therapy uses targeted lipid nanoparticles (tLNPs) to deliver CAR-encoding mRNA directly to immune cells. This announcement marked one of the first clinical applications of in vivo CAR-T technology. ...
The proteins used in VLP formation are often derived from the virus itself, ensuring that the resulting particles present the same epitopes that can trigger an immune response. This feature is particularly advantageous in vaccine development, where the aim is to elicit an immune reaction without exposing individuals to pathogenic viruses. ...
Immunomodulatory therapies aim to enhance the immune system’s ability to recognize and eliminate viral pathogens. In 2024, the development of monoclonal antibodies and immune checkpoint inhibitors is at the forefront. These agents can be tailored to enhance the immune response specifically against viruses and are being tested in combination ...
At present, peptide drugs have shown broad application prospects in the treatment of tumors, hepatitis, diabetes, and AIDS.Antibody-Based TherapyAntibodies are proteins produced by the immune system that can bind to specific markers on cells or tissues. In cancer treatment, monoclonal antibodies (mAbs) can directly kill cancer cells, prevent the development of ...
Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. ...
Mechanism of Vaccine Adjuvants Vaccine excipients, including adjuvants, are added to vaccine formulations to enhance the immune response by providing necessary signals to the immune system. Adjuvants can stimulate the innate immune system, improving the recognition of antigens and promoting a more robust adaptive immune response. ...
It is involved in the formation and development of the tumor microenvironment (TME) and plays an important role in regulating immune responses. Researchers state that enoblituzumab, as a new treatment approach, primarily works by relieving the inhibition of the immune system's recognition and elimination of cancer cells by B7-H3. ...
In addition, it aids in the development of regulatory T cells (Tregs), thereby producing peripheral T cell immune tolerance, as well as regulating the proliferation and differentiation of activated T cells. ...
Here, using a genetic timestamping system in mice, we show that persistent PCs accrue in bone marrow at an approximately constant rate of one cell per hour over a period spanning several weeks after a single immunization with a model antigen. Affinity-based selection was evident in persisting PCs, reflecting a relative and dynamic rather than absolute affinity ...
Attenuated vaccines have become one of the important development directions due to their potential advantages in terms of immune effects, for example, attenuated influenza vaccines can be inoculated by intranasal spray that is simpler, economical, painless, and consistent with the natural route of infection; they can retain the natural structure of all or most antigens of the ...
Pre-clinical in vivo data of the combination of AFM13 with PD1-blockade showed synergism and the potential for induction of cross-talk between innate and adaptive immunity.3 Based on these findings, we conducted a Phase 1b study evaluating the safety and tolerability of AFM13 in combination with pembrolizumab in patients with R/R Hodgkin ...
The ultimate goal of cancer vaccines is to fully activate the immune system so that it can recognize tumor antigens and eradicate tumor cells, and nanotechnology possesses the qualities required to do this. Nanovaccine technology, as one of the candidates for cancer immunotherapy with configurable components and sequential integration, will most likely be a method and platform to ...
In recent years, immune-based cancer treatment methods have given doctors and patients a lot of hope. ...
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). ...
But the most fundamental issue still seems to be that many proteins are not recognized by animal immune systems, which generate the polyclonal sera used as reagents in these assays. ...
The authors studied the effects on reproductive performance, carotenoid‐based ornamentation and cellular immune responsiveness of adult partridges, and their relationship with changes in oxidative stress biomarkers and plasma biochemistry. The authors also studied the effect of parental exposure on egg antioxidant content and on the survival, growth and cellular ...
These properties may lead to various physiological actions such as reducing cholesterol and attenuating blood glucose, maintaining gastrointestinal health, and positively affecting calcium bioavailability and immune function. Moreover, based on their physiochemical properties, many of the new sources of dietary fibre can help to improve the health benefits of new ...