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Immune Cell Articles & Analysis
165 articles found
Patient-specific cell collection, genetic modification, and reinfusion introduce high costs, long timelines, and scalability challenges. ...
In the vascular system, LPA production promotes endothelial cell migration and angiogenesis. Knockout studies in mice reveal impaired vessel formation and developmental defects, underscoring ENPP2’s importance in vascular biology. In the immune system, ENPP2 regulates chemotaxis of lymphocytes and monocytes, guiding immune ...
In surgical tissue recovery, focus is on controlling infection, managing inflammation, and ensuring wound closure. Beneath the surface—anatomically and biologically— the extracellular matrix (ECM) is undergoing remodeling ensure long-term tissue integrity. The ECM is a dynamic, biologically active network that orchestrates the entire process of tissue repair, remodeling, and ...
The most well-known, the K48-linked chain, is the classic "kiss of death," marking the protein for destruction by the cell's recycling plant, the proteasome. However, other chains, like the K63-linked one, send non-destructive signals involved in crucial processes like DNA repair and immune signaling. ...
This article delves into the significance of recombinant protein expression services specifically utilizing CHO cells, exploring the advantages, methodologies, and applications. The Significance of CHO Cells CHO cells are mammalian cells that originated from the ovary of the Chinese hamster and have been widely adapted for ...
Importance in Autoimmunity In autoimmune diseases, the body’s immune system attacks its own tissues, often triggered by cross-reactivity. ...
Acting as chemoattractant molecules, chemokines are central to both innate and adaptive immunity, influencing not only immune surveillance but also wound healing and angiogenesis. ...
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. ...
Understanding Antibodies and Their Mechanisms Antibodies, or immunoglobulins, are Y-shaped proteins that play a crucial role in the body’s immune response. They work by binding to foreign molecules, known as antigens, which can be proteins, polysaccharides, or other substances found on pathogens or abnormal cells. By binding to these antigens, antibodies ...
Bacteria like brucella abortus are intracellular—they hide inside our cells, using them as shelters. Many antibiotics, such as gentamicin, struggle to enter these cells, meaning they can’t reach high enough concentrations inside the cells to kill the bacteria effectively. ...
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When multiple administrations occur polyethylene glycol gets recognized by the mononuclear phagocytic system as a foreign substance which activates the immune system and results in the fast clearance of the substance thus preventing the drug from reaching target cells. ...
They can be produced in microbial systems such as yeast or bacteria, which reduce the complexity and cost associated with mammalian cell culture. Reduced Immunogenicity: Due to their smaller size and unique structure, single-domain antibodies tend to elicit a lower immune response in humans, making them safer for therapeutic applications. Production Process of ...
In this article, we will explore what cytokines and chemokines are, the significance of the Rat Cytokine and Chemokine Panel, and how it enhances our understanding of immune responses in rats. What Are Cytokines and Chemokines? Cytokines are small proteins secreted by cells that have a profound influence on the behavior of other cells. They act ...
Cytokines are small proteins that play a crucial role in cell signaling, particularly in the immune system. They regulate inflammation, immunity, and hematopoiesis, making them essential for understanding various biological processes and disease mechanisms. ...
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of three key ...
Traditional cancer treatments often lack the specificity necessary to target malignant cells while sparing healthy tissues. Alfa Cytology's immune checkpoint inhibitor services are specifically designed to address these challenges by offering customized, high-quality solutions that are tailored to the unique immunological characteristics of different cancers. ...
Immuno-oncology is an innovative field that utilizes the body’s immune system to combat cancer. By harnessing the natural capabilities of the immune system, immuno-oncology services are revolutionizing the way we approach cancer treatment, offering novel therapies that are changing the prognosis for many patients. Understanding Immuno-Oncology ...
In vitro testing involves studying immune responses in controlled laboratory environments using cell cultures. This method allows researchers to assess the direct effects of substances on immune cells and mechanisms. By analyzing changes in cell proliferation, cytokine production, and apoptosis, scientists can ...
The cell cycle is an essential biological process that enables cells to grow, duplicate their DNA, and divide into daughter cells. ...
Mouse models play a pivotal role in this field, as their immune system shares many similarities with that of humans. A key aspect of studying the immune system involves analyzing cytokines, chemokines, and growth factors—molecules that regulate immune responses and influence disease progression. The Mouse Luminex Cytokine Assay has emerged ...