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In Vitro Model Articles & Analysis
46 articles found
There is currently no standardized in vitro model for assessing the effects of dry cannabis ...
Vascular Calcification Studies In vitro models of vascular calcification—such as cultured vascular smooth muscle cells (VSMCs) treated with phosphate—use recombinant MGP to assess its ability to prevent calcium deposition. ...
One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. ...
These approaches often include in vitro and in vivo testing, as well as computational modeling. In vitro testing involves studying immune responses in controlled laboratory environments using cell cultures. ...
Traditionally, drug discovery relied on simple in vitro systems or animal models that often failed to replicate the complexity of human diseases. These conventional models frequently provided misleading results, leading to high failure rates in clinical trials. ...
Types of ADME Testing Services To ensure comprehensive evaluation, various testing methodologies are employed, including in vitro and in vivo studies, alongside computational modeling techniques. In vitro tests often involve using cell cultures or biological fluids to assess how drugs are absorbed and metabolized. ...
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation ...
Additionally, to delve deeper into cancer pathogenesis, Alfa Cytology also provides in vivo and in vitro cancer model customization services, providing versatile models that simulate diverse cancer types and stages. ...
Determine Cytotoxicity and EfficacyEvaluating the toxicity and killing effects of ADC on target cancer cells through in vitro and in vivo models is a key step in verifying its efficacy. These tests can help determine effective doses and potential side effects, thereby guiding the design of clinical trials.4. ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. Benefits and advantages of iPSC differentiation to ...
Immunogenicity assessment involves a multifaceted approach, including in vitro studies, animal models, and clinical trials, to thoroughly evaluate the immunogenic potential of a candidate molecule. ...
This wound dressing effectively promoted cell adhesion, proliferation and migration in vitro. In a full-layer wound model of mice, it could accelerate wound healing, greatly improve collagen deposition, and restore dermal and epidermal structures and skin appendages. * EDC—1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, * ...
The complexity and diversity of these conditions necessitate the development of detailed medical models for a comprehensive understanding of the diseases. Over time, Type 1 and Type 2 Diabetes Mellitus Models, Metabolic Disease Models, and generalized Diabetes Models have become integral to diabetes research and treatment ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
With the continuous development of various in vitro and electronic models, it is now possible to predict the immunogenicity of HCP impurities based on their amino acid sequences. However, these models have limited experience in clinical trials and their correlation with clinical outcomes has yet to be investigated in more depth, thus the ...
Studies have shown that CPP-paclitaxel compounds are more effective than paclitaxel alone in both in vitro cell cultures and animal models. The activity of the drug was also observed in paclitaxel-resistant cells. ...
These models stem from animal models to in vitro and in silico models, each playing a unique role in observing the disease. ...
In order to maintain efficient growth, proliferation, and differentiation during in vitro cell culture, many cell cultures require the addition of various cytokines. ...
Organoids can be started from two main types of stem cells: (1) pluripotent embryonic stem (ES) cells or synthetically induced pluripotent stem (iPS) cells and (2) organ-restricted stem cells. In vitro models of SARS-CoV-2 infection are critical for understanding the host and viral factors that support cellular tropism and the viral replication cycle. ...
IVS provides services to develop heart failure models driven by genetic mutations. Current projects include phenotyping of patent-specific engineered heart tissues (EHTs) for Duchenne muscular dystrophy and congenital heart disease. ...