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Liver Model Articles & Analysis
11 articles found
In oncology, elevated ENPP2 expression enhances LPA-mediated signaling, driving tumor proliferation, invasion, and metastasis in breast, ovarian, and liver cancers. Experimental models show that inhibiting ENPP2 reduces tumor growth and limits metastatic potential, providing a strong rationale for therapeutic intervention. ...
Such models allow for controlled studies in vitro, facilitating the examination of cellular mechanisms, lipid metabolism, and the effects of specific compounds on liver cells. ...
The corresponding author of this article is Harvard Medical School Investigator Mark Cobbold, whose team focuses on the development of new immunotherapies, having previously investigated the combination of anti-PD-1 and anti-vascular endothelial growth factor receptor 2 inhibitors in liver cancer, among other things. MOA Classical antibodies that target specific cancer cell ...
This bipotential cell population can be isolated, expanded, and transplanted to repopulate the damaged liver soft tissue and differentiate into mature hepatocytes in order to restore liver function when endogenous regenerative mechanisms are exhausted. ...
Developing accurate in vitro liver models to study is a critical step in better understanding the biological dynamics of our bodies and removing our dependence on animal models. In their recent publication, Allevi authors Marie Cuvellier, Frédéric Ezan, Hugo Oliveira, Sophie Rose, Jean-Christophe Fricain, Sophie Langouët, ...
Fibrosis-relatedRuminococcaceaeandVeillonellaceaespecies undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects. ...
NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an estimated prevalence of 25% worldwide, and is projected to become the leading indication for liver transplant by 2025. ...
Evaluation of potential antifibrotic therapies are limited using conventional non-human animal models, due to their inability to accurately reflect complex in vivo human biology, while 2D models lack the multicellular complexity and life span required to study fibrosis progression and regression. Utilization of a human 3D-bioprinted liver tissue ...
NAFLD is now recognized as the most common cause of chronic liver disease, with a prevalence of 25% worldwide, and is projected to become the leading indication for liver transplant by 2025. ...
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising ...
We describe here our tissue co‐culture of the fathead minnow (Pimephales promelas) HPG axis and liver (HPG‐L) as a tissue explant model that mimics in vivo results. Brain (hypothalamus), pituitary, gonad, and liver tissue explants from adult fish were examined for function both individually and in co‐culture to determine combinations and ...