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Liver Tissue Articles & Analysis

35 articles found

S9 Metabolic Stability: A Key to Drug Development

S9 Metabolic Stability: A Key to Drug Development

At the core of S9 metabolic stability is the S9 fraction, which is a liver extract obtained from a homogenate of liver tissues, typically from certain rodent species. ...

ByCreative Bioarray


Regulation of Lipid Metabolism in the Intestinal Flora

Regulation of Lipid Metabolism in the Intestinal Flora

Dysbiosis of the intestinal flora is associated with a variety of human metabolic diseases, such as obesity, diabetes mellitus, and nonalcoholic fatty liver disease. Regulation of lipoprotein metabolism by intestinal flora The intestine is not only a site of lipid digestion and absorption, but also a place where a large number of microorganisms reside. ...

ByCreative Proteomics


AMPK Signaling Pathway and Function

AMPK Signaling Pathway and Function

AMPK can stop the metabolism of rapid tumor proliferation as well as restore the normal function of liver and other tissues in diabetic patients is a hot topic in disease research. ...

ByCreative Proteomics


Applications of the High Polymers in Medical Science

Applications of the High Polymers in Medical Science

Macromolecule/high polymers can be used in surgery, suture, orthopedic fixation and tissue repair. They can also be used as drug carrier materials in drug controlled release systems. ...

ByAlfa Chemistry


Research Progress of Tetrahydrocurcumin

Research Progress of Tetrahydrocurcumin

The results of the present study also suggest that the antioxidant effect of tetrahydrocurcumin may be related to the increase of oxidative stress. 3.Anti-fatty Liver Effect Pan Xuefeng et al. studied the anti-fatty liver effect of tetrahydrocurcumin on human liver cell line L02 induced by oleic acid in vitro and in vitro, and the results showed ...

ByHunan Huateng Pharmaceutical Co. Ltd.


Significance of Diagnostic Enzyme Detection

Significance of Diagnostic Enzyme Detection

Enzyme synthesis and secretion in normal tissues are enhanced. In the case of tissue damage, the activity of serum is increased. ...

ByCreative Enzymes


Introduction to Lipogenesis, Lipid Anabolism and Catabolism

Introduction to Lipogenesis, Lipid Anabolism and Catabolism

Obesity is caused by excessive expansion of white adipose tissue. When nutrient intake is excessive, adipose tissue expands through either adipocyte hypertrophy or hyperplasia. ...

ByCreative Proteomics


What are Strongyloides?

What are Strongyloides?

The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. ...

ByCreative Diagnostics


Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Production

Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Production

Weight loss Canagliflozin reduce energy through the action of urine sugar, and at the same time induce the browning of white adipose tissue. Since there are two main types of fat in humans, namely white fat and brown fat, the former stores energy and the latter produces heat and consumes energy, so brown fat is increased. ...

ByHunan Huateng Pharmaceutical Co. Ltd.


Cell Transplantation Promising for Treatment of Biliary Diseases   

Cell Transplantation Promising for Treatment of Biliary Diseases  

This bipotential cell population can be isolated, expanded, and transplanted to repopulate the damaged liver soft tissue and differentiate into mature hepatocytes in order to restore liver function when endogenous regenerative mechanisms are exhausted. ...

ByCreative Biolabs


Exercise in the morning or in the evening has a completely distinct effect!   

Exercise in the morning or in the evening has a completely distinct effect!  

The mice were placed into two experimental groups: one that exercised on a treadmill for an hour in the early morning (early light) or evening (early dark), and one that did not. Following the exercise, tissues from various parts of the mice were collected, including serum, skeletal muscle, liver, epididymal white adipose tissue (eWAT), ...

ByCreative Biolabs


Application of Enzyme Detection in Clinical Diagnosis

Application of Enzyme Detection in Clinical Diagnosis

Enzyme synthesis and secretion in normal tissues are enhanced. In the case of tissue damage, the activity of serum is increased. ...

ByCreative Enzymes


Bioprinting Algae To Improve Tissue Oxygenation

Bioprinting Algae To Improve Tissue Oxygenation

The next great symbiotic relationship for humans could be between fabricated tissues and pond scum. Allevi Authors at Harvard Medical School and Brigham and Women’s Hospital recently published their findings on the use of algae in tissue engineering. ...

ByAllevi, Inc.


Improved 3D Liver Model Could Forever Change Drug Testing – Allevi Author

Improved 3D Liver Model Could Forever Change Drug Testing – Allevi Author

The liver plays an incredibly important role in the human body by metabolizing drugs and other compounds. ...

ByAllevi, Inc.


Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. ...

ByKoBioLabs


Cells isolated from donors with nonalcoholic fatty liver disease exhibit disease phenotypes in 3D bioprinted human liver tissue

Cells isolated from donors with nonalcoholic fatty liver disease exhibit disease phenotypes in 3D bioprinted human liver tissue

Publication Summary: The identification of targets and biomarkers and development of therapeutics for nonalcoholic fatty liver disease (NAFLD) may be accelerated by the use of well-characterized primary cell and tissue reagents, as well as improved in vitro human cell-based disease models, including three-dimensional (3D) bioprinted liver ...

ByOrganovo Holdings Inc.


HBOT for Complementary Therapy

HBOT for Complementary Therapy

The theory is simple, the body’s tissues need a specific intake of oxygen to function under normal conditions. When the body’s tissues are injured, the body needs supplemented levels of oxygen to activate its natural healing properties. ...

ByOXYHELP INDUSTRY


Modeling NAFLD using 3D bioprinted human liver tissue

Modeling NAFLD using 3D bioprinted human liver tissue

Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an ...

ByOrganovo Holdings Inc.


	 A human in vitro three-dimensional bioprinted liver tissue system can be used to model nutritional damage and protective effects of MSDC-0602K, a novel modulator of the mitochondrial pyruvate carrier (MPC)

A human in vitro three-dimensional bioprinted liver tissue system can be used to model nutritional damage and protective effects of MSDC-0602K, a novel modulator of the mitochondrial pyruvate carrier (MPC)

Publication Summary: The growing global incidence of NASH mirrors the availability of nutrients. Over-nutrition also results in insulin resistance and type-2 diabetes, which are often co-morbidities associated with NASH and are known to drive more adverse outcomes. MSDC-0602K, a modulator of the mitochondrial pyruvate carrier (MPC), is in clinical trials as a potential treatment for NASH. ...

ByOrganovo Holdings Inc.


	 Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis

Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis

Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. ...

ByOrganovo Holdings Inc.

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