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Lung Cell Articles & Analysis
48 articles found
In the world of preclinical lung cancer research, seeing a tumor is only half the battle. While traditional imaging like microCT can show us where a mass is located, it often fails to tell the full story: How is that tumor actually affecting the animal’s ability to breathe? A recent pilot study by Smith et al (2025) has broken new ground by combining two powerhouse technologies - ...
Abstract Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases ...
When PD-1 molecules on platelets interact with anti-PD-1 on tumor cells they release drugs that eliminate regulatory T cells while boosting CD8+ T cell functions which helps decrease tumor recurrence and metastasis after surgery. ...
At that time, based on identification of recurrent genomic alterations in the eight most deadly cancers and their ranking on the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), NGS was recommended for advanced non-squamous non-small-cell lung cancer (NSCLC), prostate cancer, ovarian cancer and cholangiocarcinoma. ...
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its ...
Bispecific antibodies have two antigen-binding arms, one of which binds to the target antigen and the other to the labeled antigen on the effector cells. The latter can activate the effector cells to target and kill tumor cells. ...
Mesenchymal stem cells are multi-potent stromal cells capable of differentiating into various cell types like osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells). They were initially identified in the bone marrow, but have since been found in various other tissues ...
Influenza A virus, strain: A/Puerto Rico/8/1934 (H1N1) was obtained from Friedrich-Loeffler-Institute, Federal Research Centre for Virus Diseases of Animals, Tuebingen, Germany, and passaged on MDCK II cells in a BSL 2 laboratory. Calu-3 cells (Homo sapiens lung epithelial cells) and MDCK II cells (Canis ...
Extracellular vesicles (EVs): Small vesicles called EVs are expelled by cells. They contain a range of biomolecules, such as lipids, proteins, and nucleic acids. ...
Different from the approved indications of Trodelvy, Dato-DXd plans to use advanced non-small cell lung cancer (NSCLC) as the first indication. In addition to single-target Trop-2 ADCs, some companies are also deploying dual-target ADCs. ...
The use of IgG-type SignalTACs to treat HER2+ cell lines (SKBR3, BT474, and SKOV3) showed that SignalTACs Ab1-Ab6 induced degradation in all three cell lines. ...
Cystic fibrosis (CF) is a rare genetic disorder that affects the lungs, digestive system, and other organs. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a protein that regulates chloride ions transport across cell membranes. ...
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. ...
CADM1 is involved in mediating interactions between cancer cells and immune cells, such as T cells and natural killer (NK) cells. ...
Therefore, quantum dot-labeled microspheres can be used for multiplex detection of miRNA overexpression in human lung cancer cells. Fluorescent Microspheres for Protein Detection Multi-color quantum dot-bound microspheres have been widely proven to be used for the simultaneous detection of multiple antigens, including IgG, tumor markers, and pathogenic markers. ...
Introduction - MMP-3 MMP-3, also known as stromelysin-1, is a key member of the MMP family. It is synthesized in cells as a proenzyme form (pro-MMP-3) and consists of 477 amino acids. ...
Potent cytotoxic drugs can be targeted to tumor cells with chemotherapeutic cytotoxic properties by means of selective monoclonal antibodies against specific or preferentially expressed antigens on target cells. ...
By comparing the toxicity of chitosan oligosaccharides with different molecular weights and different degrees of deacetylation to prostate cancer cells PC3, lung cancer cells A549 and liver cancer cells HepG2, the researchers found that chitosan with low molecular weight and low degree of deacetylation has Better anti-tumor ...
ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases. ...
Sibylla Biotech has discovered one structural drug discovery target, showing two potential drug binding pockets in the intermediate folding structures of ACE2, a protein normally found on the surface of lung cells (and of other organs such as heart and gut), exploited by the SARS-CoV-2 virus as its entry gate to the cell. ...