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Metabolic Changes Articles & Analysis
22 articles found
Automation and real-time monitoring systems enhance the efficiency of the manufacturing process, allowing for precise adjustments in response to metabolic changes in the cell culture. Quality Assurance in Antibody Production Ensuring the quality and consistency of the produced antibodies is paramount. ...
Investigations into the mechanisms of podocyte injury are ongoing, with a focus on understanding how factors like inflammation, oxidative stress, and metabolic changes contribute to podocyte damage. By elucidating these pathways, researchers hope to identify potential therapeutic targets to prevent or reverse kidney damage. ...
Various factors contribute to this phenomenon, including genetic mutations, alterations in drug targets, enhanced drug efflux, and changes in metabolic pathways. In cancer, the heterogeneity of tumors often results in a subset of cells that can survive initial treatments, leading to relapse and metastasis. ...
One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular activities and metabolic dynamics of living systems. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. ...
SpectroscopyEvaluate the efficiency of oxidative phosphorylation by measuring the change in absorption or fluorescence spectra of certain components in the mitochondrial respiratory chain.2. ...
Many abnormal physiological states are associated with disorders of lipid metabolism. Studying the changes of lipids in different states of the organism at the systemic level can help analyze the mechanisms of lipid metabolic networks. ...
Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and their change patterns, thus studying the nature of the occurrence and development of collective life activities. ...
Therefore, decoding information about modifications that affect sequence or structural changes is increasingly important. Methods for detecting RNA modifications Currently, most methods used to detect RNA modifications fall into three categories: high-throughput whole-transcriptome sequencing technologies, mass spectrometry methods, and bioinformatics analysis. ...
Case Study Description Warming Waters and Metabolic Rates As climate change continues to warm our world and its waters, scientists and researchers across the globe have spent years attempting to understand and predict the ramifications such warming will have on Earth’s ecosystems. ...
Her team's imaging shows how the metabolism of the mouse brain changes when glycolysis is blocked in neurons. ...
Pancreatic cancer is a highly malignant digestive system tumor, and the five-year survival rate of patients after diagnosis is only about 10%. Changes in metabolism are one of the important features of tumor cells. Tumor cells undergo metabolic reprogramming to generate the substances, energy, and redox forces required for their rapid ...
These authors investigated multiple metabolic modifications of hPSC-CMs. They also determined the role of a metabolic switch from glycolysis to fatty acid oxidation in hPSC-CMs generated in the laboratory by protein induction called peroxisome proliferator activated receptor delta (PPARd). This metabolic switch is a critical part of the heart ...
Increasing sialyation will also increase the local negative charge, thereby physically destroying cell adhesion and promoting detachment from the tumor mass through electrostatic repulsion to enhance tumor cell invasion. In general, changes in genetic, epigenetic, metabolic, inflammatory and microenvironmental mechanisms during cancer progression are closely ...
In the long course of human evolution, gut microbiota has also evolved and provided important metabolic pathways for the body, such as those involved in the metabolism of indigestible dietary components and exogenous substances, as well as the production of vitamins and essential amino acids. ...
I didn’t want to heat the local tissue in this case, but I did want to create metabolic changes at the cellular level to speed healing. As I performed my manual lymphatic drainage techniques, I did use the diathermic effect of the capacitive electrode to dilate lymph vessels and vascular tissue proximal to the injury so that fluid drained from the surgical ...
Systemic complications include cachexia, paraneoplastic syndromes, electrolyte abnormalities, metabolic alterations, and hematologic changes. These symptoms are a frequent cause of hospitalization. ...
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). ...
Taxonomic and functional analyses of gut microbiota showed significantly higher cecum bacterial diversities and abundances including genus Bilophila, Dorea, and Dehalobacterium in L. fermentum KBL375-treated mice. Metabolic analysis of the cecum also showed significant changes in the levels of various amino acids including methionine, phenylalanine, serine, and ...
These results highlight a neddylation-dependent mechanism regulating gene expression in the liver that is disrupted in early metabolic liver disease and may contribute to the progression to NASH, cirrhosis, and ultimately hepatocellular carcinoma. ...