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24 articles found
Comparative genomic analyses reveal that commercially available L. acidophilus powders differ markedly in key functional elements: Bacteriocin production genomics: Strains such as L. acidophilus NCFM contain complete operons for lactacin B production, while others (e.g., La-14) exhibit truncated bacteriocin genes, resulting in differential antimicrobial capacities. Carbohydrate ...
Their capacity to hold large DNA inserts allows for comprehensive genomic studies, including genome sequencing projects, structural genomics, and gene identification. Moreover, fosmid libraries facilitate the recovery of entire gene clusters and operons, which is particularly useful when studying organisms with complex genetic architectures. This capability is ...
Dysregulation of sugar nucleotide metabolism has been implicated in a number of diseases, including cancer, diabetes, and congenital disorders of glycosylation. ...
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. ...
Such models play a crucial role in better understanding the pathophysiology of diabetes, evaluating novel therapeutic strategies, and predicting the short- and long-term outcomes of different treatments on glucose metabolism and diabetes-related complications. Metabolic Disease Models Metabolic diseases encompass a wide range of conditions ...
The following steps are included in the genetic engineering process: Target Gene Identification: The first step is to locate the genes that are responsible for the desired attribute using genome sequencing or metabolic pathway research on yeast. Gene Modification: CRISPR-Cas9 or homologous recombination are two genetic ...
To determine exactly how neurons use the products of metabolizing glucose, the team used CRISPR gene editing to remove two key proteins from the cells. ...
This phenotype is mainly due to the upregulation of lipogenesis-related genes at multiple levels of transcriptional, translational and post-translational modifications, and enzymatic activity, as well as the impact on oncogene expression due to changes in these genes or lipid metabolism. ...
. * Whole transcriptome analysis: genes related to proliferation were up-regulated and genes related to the regulation of immune system processes (e.g., MUC1, MUC5B), inflammatory response-related genes (e.g., IL1LR1, GPX4, ADCY5) and extracellular matrix tissue-related genes (LAMB3, MMP1) were down-regulated, suggesting that ...
This question is answered in a recent publication published in Cell Metabolism. Researchers discovered, using a mouse model, that exercise at different times of the day has varied impacts on local and systemic metabolism. ...
In humans and mammals, alcohol dehydrogenase and aldehyde dehydrogenase (ALDH) constitute the alcohol dehydrogenase system, which is involved in ethanol metabolism in vivo and is an important metabolic enzyme in humans and animals. ...
Compared with other previously unknown organs, the microbiota has extensive metabolic functions and carries 1,000 times more genes than the human genome. ...
The metagenome analysis also reveals the relationship between significantly downregulated microbial genes related to primary/secondary bile acid metabolism and increasing amounts of total conjugated bile acids and unconjugated primary bile acids in non-obese subjects with significant fibrosis. ...
These findings were consistent with KEGG analyses showing that administration of KBL382 resulted in increased levels of genes associated with metabolism. Moreover, KBL382 administration can affect the amino acids and SCFAs production (Figure 8A–C). ...
As few studies have addressed the toxicity of these specific phthalates in most organisms, this study used higher concentrations of these chemicals to determine their toxicity pathways in amphibians and at the same time investigate a suite of genes known to be altered by the well‐studied phthalates. Both DMP and DCHP increased larval mortality (9.1 to 924.0 mg/L DMP and 4.1 to ...
We studied the impacts of Cd on carbohydrate as well as on the protein metabolism, metallothionein (MT), glutathione (GSH) synthesis, energy‐related parameters and mRNA expression of genes involved in energy metabolism. ...
In vivo, hypoxia can either i) inhibit proliferation or the spread of cancer, stop differentiation, cause apoptosis or cell death; or ii) promote the down regulation of tumor suppressor genes and development of an aggressive phenotype resistant to therapeutic intervention (Reference Section; 4, 8). ...
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Transcriptional profiling using cDNA microarrays and follow-on quantitative real-time PCR analysis revealed a relative derepression of aerobic metabolism genes in carbon monoxide (CO)-induced anoxia when compared to nitrogen (N2) gas-induced anoxia, which is consistent with the known oxygen-mimetic effects of CO. ...
The diversity and distribution of a bacterial community from Coffee Pots Hot Spring, a thermal spring in Yellowstone National Park with a temperature range of 39.3 to 74.1°C and pH range of 5.75 to 6.91, were investigated by sequencing cloned PCR products and quantitative PCR (qPCR) of 16S rRNA and metabolic genes. The spring was inhabited by three Aquificae ...
Using DNA microarray and quantitative reverse transcription-PCR (RT-PCR) analyses, we found that sigB disruption led to reduced transcript levels of genes involved in the metabolism of glucose into organic acids. This in turn resulted in retardation of glucose consumption by cells under conditions of oxygen deprivation. These results indicate that SigB is ...