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Plasma Protein Articles & Analysis
18 articles found
This involves assessing how a drug binds to plasma proteins and how it penetrates various tissues. Understanding distribution patterns helps in predicting the drug’s therapeutic effects as well as potential side effects. ...
Plasma proteomics is an emerging field of science dedicated to the analysis and understanding of the protein composition in the plasma and its functions. ...
Subjects with a clinical diagnosis of preeclampsia at the time of enrollment were excluded. GlyFn, pregnancyassociated plasma protein-A2 (PAPPA2), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured by immunoassay. ...
For efficient fusion and entry, the SARS-CoV-2 spike protein needs to be cleaved by suitable host cell proteases on the cell surface like TMPRSS2. ...
These proteins are found in the plasma membrane and normally provide the cell's resistance to viruses. ...
The signal molecule usually binds to a receptor protein that is embedded in the plasma membrane of the target cell. The receptor activates one or more intracellular signaling pathways, involving a series of signaling proteins. Finally, one or more of the intracellular signaling proteins alters the activity of effector ...
With both strategies, fluid that is isotonic and isonatremic to plasma is slowly removed, leading to both total body sodium and water loss while maintaining stable hemodynamics and preserving renal perfusion. ...
Lyophilization in biotechnology is the process of freeze-drying, removing moisture content from a product at low temperature until it is no longer biologically or chemically active. Microbes, proteins, pharmaceuticals, plasma, and tissues are just a few examples of the many heat-sensitive things that can be preserved with the freeze-drying technique. ...
ByFireGene
Cardiolipids are structurally unique phospholipids located primarily in the inner mitochondrial membrane, where they control mitochondrial respiration and act as a signaling platform in the induction of apoptosis. 3、Protein acylation The abundance and saturation of cellular fatty acids determine the activity of signaling proteins that require acylation ...
NTLA-2001 therapy, an in vivo gene editing therapy, delivers mRNA sequences carrying sgRNAs targeting the disease-causing TTR gene and optimized spCas9 protein to the liver via a lipid nanoparticle (LNP) vector. Clinical data previously reported in the NEJM revealed that three of the six patients treated received the 0.1 mg/kg dose, whereas three received the 0.3 mg/kg dose. ...
The paper demonstrates how a computational platform integrating machine learning optimization with mechanistic modeling can be used to simulate compound plasma concentration profile and predict tissue-plasma partition coefficients with high accuracy by varying the lipophilicity descriptor logP. ...
In addition, the proportion of CRP (C-reactive protein) and SAA (serum amyloid A) increased before death was 85% and 100%, respectively. CRP is an inflammatory marker, which plays an important role in host defense against invading pathogens and inflammation. SAA is a plasma protein, which transports lipids in the process of inflammation. ...
Additionally, the liver has an abundance of other functions including [iv]: Production of bile, which helps carry away waste and break down fats in the small intestine during digestion Production of specific proteins for blood plasma Production of cholesterol and special proteins to help carry fats through the body Store and release glucose ...
ByAlgatech
Additionally, the liver provides these functions: Production of bile, which helps carry away waste and break down fats in the small intestine during digestion Production of specific proteins for blood plasma Production of cholesterol and special proteins to help carry fats through the body Store and release glucose as needed Processing of ...
ByAlgatech
The late endosome (MVB) plays a key role in coordinating vesicular transport of proteins between the Golgi complex, vacuole/lysosome, and plasma membrane. ...
We report a quantitative proteomic evaluation of the targets and effects of the inhibitor in this cell-based system. Proteins in cell-conditioned medium (the secretome) and membrane fractions with levels that were modulated by the MMPI were identified by isotope-coded affinity tag (ICAT) labeling and tandem mass spectrometry. Comparisons of the expression of MMP-14 with that of a ...
NAG1 encodes a 19-kDa protein, detected by Western blotting of hemagglutinin (HA)-tagged Nag1p with anti-HA antibodies and by β-galactosidase analysis of a NAG1-lacZ fusion. NAG1 is evolutionarily conserved as a unit with YGR031W in bacteria and fungi. Unlike the YGR031WP protein product, however, which localizes to the mitochondria, Nag1p localizes to the ...
The study of eukaryotic membrane proteins has been hampered by a paucity of systems that achieve consistent high-level functional protein expression. ...