Gleason Score Articles & Analysis
7 articles found
Pathology as it is practiced today in labs around the world is not all that different from the pathology of the 19th century. The microscope has changed relatively little since then, and Hematoxylin and Eosin (H&E) stained slides remain the bread and butter of the pathologist. Yet it is not for lack of technological development; in recent years, digital pathology whole slide scanners, digital ...
BACKGROUND Non-invasive techniques like urinary biomarkers and multiparametric Magnetic Resonance Imaging (mpMRI) show great promise for the detection of clinically significant prostate cancer (PCa), leading to a reduction of over-diagnosis and over-treatment. Apart from yet to be established diagnostic accuracy is the systematic use of mpMRI challenging due to the high cost of setting up, ...
Organizations Martini-Klinik Prostate Cancer Center and Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, MDxHealth, B.V., Nijmegen, Netherlands, MDxHealth, Inc., Irvine, CA, Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium, Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany Abstract ...
Abstract Objective: To evaluate an epigenetic assay performed on tissue from negative prostate biopsies in a group of African American (AA) men undergoing repeat biopsy, and to compare accuracy for predicting repeat biopsy outcome to prior studies conducted in predominantly Caucasian populations. Materials and methods: The study population consisted of 211 AA men from 7 urology centers ...
Summary OTraces, in collaboration with the Johns Hopkins Medical Center, Brady Urology Institute (JHMC), performed a blinded validation study on OTraces prostate cancer (PCa) detection products. The blinded validation project involves two phases, and the first has been completed: Phase I: Blinded third party validation of the test for men with aggressive PCa, Gleason score of 7(4+3), 8, 9, and ...
Abstract Background: Prostate cancer (PCa) diagnosis is challenging because efforts for effective, timely treatment of men with significant cancer typically result in over-diagnosis and repeat biopsies. The presence or absence of epigenetic aberrations, more specifically DNA-methylation of GSTP1, RASSF1, and APC in histopathologically negative prostate core biopsies has resulted in an ...
ABSTRACT Urethral strictures (US) can be recurrent chronic illnesses leading to severe side effects and poor quality of life. Several options to treat US exist, including repeated dilatations, stents, and open surgery. A urethral stent is a good, minimally invasive option but has major limitations, such as stent migration, mucosal growth, and incontinence, especially for bladder-neck strictures. ...